Alessandro S. Spinelli

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A number of spike detection and sorting methods exist and the availability of powerful desktop computers may suggest that the problem of spike detection is solved. However, for portable multi-channel systems, when one takes into account the power consumption limitations, computationally simple methods can be advantageous when compared to more complex(More)
OBJECTIVES To study the modifications of some components of the acute phase response (APR) in Sicilian patients with boutonneuse fever (BF) caused by Rickettsia conorii. METHODS Sera from 500 Sicilian patients with confirmed BF were studied at the time of diagnosis and every week after treatment, and after recovery for the presence of various inflammatory(More)
Experimental tests have been carried out for characterizing the performance of a new single-photon avalanche diode. The detector is specifically designed for picosecond timecorrelated single photon counting, aiming to obtain a time response free from the tail effects and/or secondary bumps observed in all other available single-photon detectors. The(More)
An increasing popularity of multichannel recordings from freely behaving animals and the need to develop a practical brain-machine interface has fuelled the development of miniature multichannel recording systems. Here we describe our prototype miniature 64-channel acquisition system that could be used for multichannel recordings in freely behaving monkeys(More)
Interferon (IFN)-gamma, interleukin (IL)-10, IL-6, and tumor necrosis factor (TNF)-alpha were significantly increased in sera from Sicilian patients with acute boutonneuse fever (BF) compared with those of healthy controls. IFN-gamma levels dropped sharply within the second week after infection. IL-6, IL-10, and TNF-alpha levels gradually declined; in(More)
We present a neural amplifier that optimizes the trade-off between power consumption and noise performance down to the best so far reported. In the perspective of realizing a fully autonomous implantable system we also address the problem of spike detection by using a new simple algorithm and we discuss the implementation with analog integrated circuits.(More)
It has been noted that the power spectrum of intracortical local field potential (LFP) often scales as 1/f(-2). It is thought that LFP mostly represents the spiking-related neuronal activity such as synaptic currents and spikes in the vicinity of the recording electrode, but no 1/f(2) scaling is detected in the spike power. Although tissue filtering or(More)
This paper reports a multi-channel neural recording system-on-chip (SoC) with digital data compression and wireless telemetry. The circuit consists of a 16 amplifiers, an analog time division multiplexer, an 8-bit SAR AD converter, a digital signal processor (DSP) and a wireless narrowband 400-MHz binary FSK transmitter. Even though only 16 amplifiers are(More)