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Invasive aspergillosis (IA) has been traditionally considered an infection occurring in patients with well established risk factors, such as neutropenia, hematologic malignancies, organ transplantation, or HIV. However there is increasing evidence that apparently immunocompetent patients, such as those with severe liver disease, are also at high risk for(More)
Engineering of knowledge-intensive processes (KiPs) is far from being mastered, since they are genuinely knowledge- and data-centric, and require substantial flexibility, at both design- and run-time. In this work, starting from a scientific literature analysis in the area of KiPs and from three real-world domains and application scenarios, we provide a(More)
Dear Editor, Pneumonia occurring in patients living in the community is the most common infection leading to hospitalization in intensive care units and the first cause of death associated with infectious diseases. The mortality rate due to pneumonia has shown little improvement over time despite advances in antimicrobial therapy and improved intensive care(More)
BACKGROUND Daptomycin pharmacokinetics has not been extensively studied in patients undergoing continuous renal replacement therapy (CRRT). METHODS The aim of the study was to collect pharmacokinetics and clinical data of patients undergoing CRRT and receiving daptomycin therapy. Daptomycin was measured using an isocratic high-performance liquid(More)
BACKGROUND Pneumonia is complicated by high rate of mortality and cardiovascular events (CVEs). The potential benefit of aspirin, which lowers platelet aggregation by inhibition of thromboxane A2 production, is still unclear. The aim of the study was to assess the impact of aspirin on mortality in patients with pneumonia. METHODS AND RESULTS Consecutive(More)
BACKGROUND Higher daptomycin doses are advocated for select methicillin-resistant Staphylococcus aureus (MRSA)-related infections, but the probabilities of target attainment (PTA) and toxicity of these doses have not been characterized in critically ill patients. METHODS We evaluated the plasma pharmacokinetics (PK) and clinical outcomes of a cohort of(More)
INTRODUCTION The diffusion of multidrug-resistant (MDR) bacteria has created the need to identify risk factors for acquiring resistant pathogens in patients living in the community. OBJECTIVE To analyze clinical features of patients with community-onset pneumonia due to MDR pathogens, to evaluate performance of existing scoring tools and to develop a(More)
Process Management Systems (PMSs) are currently more and more used as a supporting tool to coordinate the enactment of processes. YAWL, one of the best-known PMSs coming from academia, allows to define stable and well-understood processes and provides support for the handling of expected exceptions, which can be anticipated at design time. But in some real(More)
Engineering of knowledge-intensive processes is far from being mastered. Processes are defined knowledge-intensive when peo-ple/agents carry them out in a fair degree of " uncertainty " , where the uncertainty depends on different factors, such as the high number of tasks to be represented, their unpredictable nature, or their dependency on the scenario. In(More)
Process Management Systems (PMSs, a.k.a. Workflow Management Systems - WfMSs) are currently more and more used as a supporting tool to coordinate the enactment of processes. In real world scenarios, the environment may change in unexpected ways so as to prevent a process from being successfully carried out. In order to cope with these anomalous situations,(More)