Alessandro Russo

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Engineering of knowledge-intensive processes (KiPs) is far from being mastered, since they are genuinely knowledge- and data-centric, and require substantial flexibility, at both design- and run-time. In this work, starting from a scientific literature analysis in the area of KiPs and from three real-world domains and application scenarios, we provide a(More)
Invasive aspergillosis (IA) has been traditionally considered an infection occurring in patients with well established risk factors, such as neutropenia, hematologic malignancies, organ transplantation, or HIV. However there is increasing evidence that apparently immunocompetent patients, such as those with severe liver disease, are also at high risk for(More)
Engineering of knowledge-intensive processes is far from being mastered. Processes are defined knowledge-intensive when people/agents carry them out in a fair degree of “uncertainty”, where the uncertainty depends on different factors, such as the high number of tasks to be represented, their unpredictable nature, or their dependency on the scenario. In the(More)
Nowadays, process-aware information systems (PAISs) are widely used for the management of “administrative” processes characterized by clear andwell-defined structure. Besides such scenarios, PAISs can be used also in mobile and pervasive scenarios, such as in coordinating operators during emergency situations [1]. In these pervasive settings, due to(More)
Providing operational support to clinicians during their daily activities in hospital wards is a challenge for information technologies. In particular, solutions should provide very usable user interfaces, possibly deployed on mobile devices, and should be able to enact and monitor the execution of clinical guidelines. In this paper, we present the(More)
BACKGROUND Higher daptomycin doses are advocated for select methicillin-resistant Staphylococcus aureus (MRSA)-related infections, but the probabilities of target attainment (PTA) and toxicity of these doses have not been characterized in critically ill patients. METHODS We evaluated the plasma pharmacokinetics (PK) and clinical outcomes of a cohort of(More)
Dear Editor, Pneumonia occurring in patients living in the community is the most common infection leading to hospitalization in intensive care units and the first cause of death associated with infectious diseases. The mortality rate due to pneumonia has shown little improvement over time despite advances in antimicrobial therapy and improved intensive care(More)
INTRODUCTION The diffusion of multidrug-resistant (MDR) bacteria has created the need to identify risk factors for acquiring resistant pathogens in patients living in the community. OBJECTIVE To analyze clinical features of patients with community-onset pneumonia due to MDR pathogens, to evaluate performance of existing scoring tools and to develop a(More)
Terlipressin bolus infusion may contribute to overshooting increases in systemic vascular resistance with concomitant reductions in systemic blood flow and oxygen delivery. Whether these effects negatively impact on microcirculatory perfusion is still not known. The objective of the present study was, therefore, to elucidate the effects of a single(More)
BACKGROUND Pneumonia is complicated by high rate of mortality and cardiovascular events (CVEs). The potential benefit of aspirin, which lowers platelet aggregation by inhibition of thromboxane A2 production, is still unclear. The aim of the study was to assess the impact of aspirin on mortality in patients with pneumonia. METHODS AND RESULTS Consecutive(More)