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Engineering of knowledge-intensive processes (KiPs) is far from being mastered, since they are genuinely knowledge- and data-centric, and require substantial flexibility, at both design- and run-time. In this work, starting from a scientific literature analysis in the area of KiPs and from three real-world domains and application scenarios, we provide a(More)
The discovery of Epidermal Growth Factor Receptor (EGFR) mutations in Non Small Cell Lung Cancer (NSCLC) launched the era of personalized medicine in advanced NSCLC, leading to a dramatic shift in the therapeutic landscape of this disease. After ten years from the individuation of activating mutations in the tyrosine kinase domain of the EGFR in NSCLC(More)
BACKGROUND Vasoconstrictive, proliferative and oxidative effects of angiotensin II (Ang II) are mediated by Ang II type 1 (AT1) receptors. The effects of Ang II via the Ang II type 2 (AT2) receptor subtype (AT2R) are less well defined. Growing evidence shows the existence of cross-talk between the Ang II receptor subtypes, which is revealed by AT1R(More)
Engineering of knowledge-intensive processes is far from being mastered. Processes are defined knowledge-intensive when peo-ple/agents carry them out in a fair degree of " uncertainty " , where the uncertainty depends on different factors, such as the high number of tasks to be represented, their unpredictable nature, or their dependency on the scenario. In(More)
Process Management Systems (PMSs) are currently more and more used as a supporting tool to coordinate the enactment of processes. YAWL, one of the best-known PMSs coming from academia, allows to define stable and well-understood processes and provides support for the handling of expected exceptions, which can be anticipated at design time. But in some real(More)
Nowadays, process-aware information systems (PAISs) are widely used for the management of " administrative " processes characterized by clear and well-defined structure. Besides such scenarios, PAISs can be used also in mobile and pervasive scenarios, such as in coordinating operators during emergency situations [1]. In these pervasive settings, due to(More)
In complex emergency/disaster scenarios, persons from teams from various emergency-response organizations collaborate to achieve a common goal. In these scenarios, the use of smart mobile devices and applications can improve the collaboration dynamically. The lack of basic interaction principles can be dangerous, as it could increase the level of disaster(More)
Process Management Systems (PMSs, a.k.a. Workflow Management Systems - WfMSs) are currently more and more used as a supporting tool to coordinate the enactment of processes. In real world scenarios, the environment may change in unexpected ways so as to prevent a process from being successfully carried out. In order to cope with these anomalous situations,(More)
Data- and artifact-centric business processes are gaining momentum due to their ability of explicitly capturing the interplay between the process control-flow and the manipulated data. In this paper, we rely on the framework of Data-Centric Dynamic Systems (DCDSs), which has been recently introduced for the formal specification and verification of(More)
INTRODUCTION The diffusion of multidrug-resistant (MDR) bacteria has created the need to identify risk factors for acquiring resistant pathogens in patients living in the community. OBJECTIVE To analyze clinical features of patients with community-onset pneumonia due to MDR pathogens, to evaluate performance of existing scoring tools and to develop a(More)