Alessandro Paolini

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The success of chemo- and radiotherapy in glioblastoma multiforme, the most common and lethal primary brain tumour, could rely on the induction of immunogenic tumour cell death and on the induction of anticancer immune response. In this study we investigated cell survival to single treatments or combination of X-rays and temozolomide in glioblastoma cell(More)
BACKGROUND Several types of cell death can induce the activation of the immune system by releasing factors of damage. AIM To identify different cell death modalities using U87 glioblastoma cell line after radio-chemotherapy treatments by analyzing the expression of HSP70 after γ-ray irradiation and temozolomide treatment. MATERIALS AND METHODS U87 cell(More)
The four High Energy Physics (HEP) detectors at the Large Hadron Collider (LHC) at the European Organization for Nuclear Research (CERN) are among the most important experiments where the National Institute of Nuclear Physics (INFN) is being actively involved. A Grid infrastructure of the World LHC Computing Grid (WLCG) has been developed by the HEP(More)
Advanced nanostructured materials, such as gold nanoparticles, magnetic nanoparticles, and multifunctional materials, are nowadays used in many state-of-the-art biomedical application. However, although the engineering in this field is very advanced, there remain some fundamental problems involving the interaction mechanisms between nanostructures and cells(More)
PURPOSE The aim of this work was to study the correlation between the expressions of the ABCA2 and ABCA3 genes at the mRNA and protein levels in children with acute lymphoblastic leukemia (ALL) and the effects of this association on multidrug resistance (MDR). MATERIALS AND METHODS Sixty-nine children with de novo ALL and 25 controls were enrolled in the(More)
In this review we reported and discussed the structural features of the ATP-Binding Cassette (ABC) transporter ABCA3 and how the use of bioinformatics tools could help researchers to obtain a reliable structural model of this important transporter. In fact, a model of ABCA3 is still lacking and no crystallographic structures (of the transporter or of its(More)