Alessandro Gubbini

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We tested the hypothesis that glutamate transporter GLT-1 (also known as EAAT2) plays a role in the regulation of prepulse inhibition (PPI) of the acoustic startle reflex, a simple form of information processing which is reduced in schizophrenia. To do this, we studied PPI in rats treated with ceftriaxone (200 mg/kg/day for 8 days), an antibiotic that(More)
Prepulse inhibition (PPI) of the startle, a valuable method to assess brain's ability to filter incoming information, is consistently altered in schizophrenics and in animal models of schizophrenia (Braff and Geyer, 1990). We have shown that ceftriaxone (CEF)-induced GLT-1 up-regulation is associated with impaired PPI, and that this effect is reversed by(More)
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