Alessandro Di Michele

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The aim of this work was to characterize lipid nanoparticles from a rheological point of view, intended for drug delivery after parenteral administration. The conditions to obtain a re-dispersible powder using freeze-drying and spray-drying have also been investigated. Lipid nanoparticles (179.9±6.2nm) were prepared with the high pressure homogenization(More)
This work concerns a comparison of the hydration properties and self-association behavior in aqueous solution of three biologically relevant simple molecules: tert-butyl alcohol (TBA), trimethylamine-n-oxide (TMAO), and glycine betaine (GB). These molecules were used as a model to study hydrophobic behavior in water solutions. In particular, water(More)
With the discovery of the bile acid (BA)-activated nuclear and membrane receptors, the role of BAs as signalling molecules in important paracrine and endocrine networks has been fully documented in the last decade. Besides regulating their own synthesis and transport, BAs have been demonstrated being involved in triggering the adaptive response to(More)
Sublethally irradiated mice primed with dinitrophenyl (Dnp)-keyhole limpet hemocyanin immediately after irradiation or 30 days later and subsequently boosted with a second injection of antigen displayed a secondary response to Dnp characterized by antibody affinity greater than that in unirradiated controls. Also, in radiation chimeras primed with(More)
Although human amniotic fluid does contain different populations of foetal-derived stem cells, scanty information is available on the stemness and the potential immunomodulatory activity of in vitro expanded, amniotic fluid stem cells. By means of a methodology unrequiring immune selection, we isolated and characterized different stem cell types from(More)
Supported iron-based Fischer-Tropsch (FT) catalysts with high loading of active metal have been prepared using both traditional and innovative methods. In these latter the impregnation of silica support has been performed by adding a step involving an ultrasound (US) or a microwave (MW) treatment to improve the metal deposition and to increase the catalyst(More)
Among the mechanisms adopted by bacteria, efflux pumps (EPs) have been recognized as being significantly involved in contributing to resistance to commonly used antibacterial agents. However, little is known about their three-dimensional structures or the steric requirements for their inhibition. Lack of such knowledge includes NorA, one of the most studied(More)
Mercury acetate (MA) can be obtained by metallic mercury immersed in a mixture of deionised, bidistillated water (dbw) and acetic acid. We show that MA crystallization time is drastically reduced if the previous mixtures are subjected to acoustic cavitation. The largest quantity of crystals is obtained by a concentration of acetic acid of about 7% in(More)
New gold catalysts supported on CeO 2 , ZrO 2 and TiO 2 were synthesized by two different techniques: deposition-precipitation and colloidal method. The role of the surfactant (PVA, PVP, THPC) was also investigated. The catalysts were tested in the oxidation of glucose to gluconic acid, in aqueous environment and under mild conditions (60 ˝ C and(More)
Reactivity of methyl naphthalene-2-sulphonate, MeONs, with H2O, Br(-) and Cl(-) in water and in cationic micelles of cetyltrialkylammonium surfactants, n-C16H33N(+)R3X(-), R=Me (CTA(+)), n-Pr (CTPA(+)), X=Br, Cl, CH3SO3, has been investigated in the temperature range 25-45°C. Micellar rate effects were analysed by using the pseudophase treatment, and the(More)