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OBJECTIVES We investigated the association between occupation and bladder cancer in a hospital-based case-control study conducted in Spain. METHODS 1219 patients with transitional cell carcinoma of the urinary bladder and 1271 controls selected from 18 hospitals in Spain between June 1998 and September 2000 provided detailed information on life-time… (More)
BACKGROUND Organochlorine compounds such as 1,1,1-trichloro-2,2-bis(p-chlorophenyl)-ethane (p,p'-DDT), 1,1-dichloro-2,2-bis(p-chlorophenyl) ethylene (p,p'-DDE), and some polychlorinated biphenyls (PCBs) are carcinogenic to animals and possibly also to human beings. Occupational exposure to DDT may increase the risk of pancreas cancer. The high frequency of… (More)
BACKGROUND Aberrant global DNA methylation is shown to increase cancer risk. LINE-1 has been proven a measure of global DNA methylation. The objectives of this study were to assess the association between LINE-1 methylation level and bladder cancer risk and to evaluate effect modification by environmental and genetic factors. METHODS Bisulphite-treated… (More)
R ecent scientific, political, industrial, and public relations efforts to publicise the first interpretations of the human genome sequence raised unprecedented social expectations towards the health sciences 1–6 ; yet, prudence seems warranted when assessing the relevance of emerging genomic knowledge to lessen the burden of illness in human populations.… (More)
Description Various statistical methods and models which are typically used for the estimation of outstanding claims reserves in general insurance, including those to estimate the claims development result as required under Solvency II. Description ChainLadder provides methods and models which are typically used in insurance claims reserving. References… (More)
The ChainLadder package provides various statistical methods which are typically used for the estimation of outstanding claims reserves in general insurance, including those to estimate the claims development results as required under Solvency II.