Alessandro Beghini

Learn More
Protein kinases of the microtubule affinity-regulating kinase (MARK) family were originally discovered because of their ability to phosphorylate tau protein and related microtubule-associated proteins (MAPs), and their role in the establishment of cell polarity in different contexts. Recent papers have indicated that microtubule affinity-regulating kinase 4(More)
The stability theories energetically associated with different finite strain measures are equivalent if the tangential moduli are transformed as a function of the stress. However, for homogenized soft-in-shear composites, they can differ greatly if the material is in small-strain and constant elastic moduli measured in small-strain tests are used. Only one(More)
Distinct forms of tyrosine kinase domain (TKD), juxtamembrane domain, exon 8, and internal tandem duplication (ITD) mutations of c-KIT, were observed in about 46% of core binding factor leukemia (CBFL) patients. To evaluate their prognostic significance, 67 adult patients with CBFL were analyzed to ascertain the c-KIT mutation status. In acute myeloid(More)
The paper presents the spectral stiffness microplane model, which is a general constitu-tive model for unidirectional composite laminates, able to simulate the orthotropic stiffness , prepeak nonlinearity, failure envelopes, and, in tandem with the material characteristic length, also the post-peak softening and fracture. The framework of the microplane(More)
Although the stability theories energetically associated with different finite strain measures are mutually equivalent if the tangential moduli are properly transformed as a function of stress, only one theory can allow the use of a constant shear modulus G if the strains are small and the material defonns in the linear elastic range. Recently it was shown(More)
The validation of clusters discovered in bio-molecular data is a central issue in bioinformatics. Recently, stability-based methods have been successfully applied to the analysis of the reliability of clusterings characterized by a relatively low number of examples and clusters. Nevertheless , several problems in functional genomics are characterized by a(More)
Acute myeloid leukemia (AML) is a genetically heterogeneous clonal disorder characterized by two molecularly distinct self-renewing leukemic stem cell (LSC) populations most closely related to normal progenitors and organized as a hierarchy. A requirement for WNT/β-catenin signaling in the pathogenesis of AML has recently been suggested by a mouse model.(More)
Gene selection methods aim at determining biologically relevant subsets of genes in DNA microarray experiments. However, their assessment and validation represent a major difficulty since the subset of biologically relevant genes is usually unknown. To solve this problem a novel procedure for generating biologically plausible synthetic gene expression data(More)
Activating mutations of KIT receptor tyrosine kinase have been reported in different neoplasms. The M541L KIT substitution (KIT(M541L)) has been described to be associated with pediatric mastocytosis, to enhance growth rate of the affected cells and to confer higher sensitivity to imatinib therapy. We investigated the presence of KIT(M541L) in five males(More)
Although, for homogeneous columns, the differences between Engesser's and Haringx's formulas for shear buckling have been explained in 1971 by the dependence of shear modulus on the axial stress, for soft-core sandwich columns the choice of the correct formula has baffled engineers for half a century. Recently, Bažant explained this difference by a(More)