Alessandro Beghini

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The stability theories energetically associated with different finite strain measures are equivalent if the tangential moduli are transformed as a function of the stress. However, for homogenized soft-in-shear composites, they can differ greatly if the material is in small-strain and constant elastic moduli measured in small-strain tests are used. Only one(More)
Although the stability theories energetically associated with different finite strain measures are mutually equivalent if the tangential moduli are properly transformed as a function of stress, only one theory can allow the use of a constant shear modulus G if the strains are small and the material defonns in the linear elastic range. Recently it was shown(More)
The validation of clusters discovered in bio-molecular data is a central issue in bioinformatics. Recently, stability-based methods have been successfully applied to the analysis of the reliability of clusterings characterized by a relatively low number of examples and clusters. Nevertheless , several problems in functional genomics are characterized by a(More)
Acute myeloid leukemia (AML) is a genetically heterogeneous clonal disorder characterized by two molecularly distinct self-renewing leukemic stem cell (LSC) populations most closely related to normal progenitors and organized as a hierarchy. A requirement for WNT/β-catenin signaling in the pathogenesis of AML has recently been suggested by a mouse model.(More)
Gene selection methods aim at determining biologically relevant subsets of genes in DNA microarray experiments. However, their assessment and validation represent a major difficulty since the subset of biologically relevant genes is usually unknown. To solve this problem a novel procedure for generating biologically plausible synthetic gene expression data(More)
Activating mutations of KIT receptor tyrosine kinase have been reported in different neoplasms. The M541L KIT substitution (KIT(M541L)) has been described to be associated with pediatric mastocytosis, to enhance growth rate of the affected cells and to confer higher sensitivity to imatinib therapy. We investigated the presence of KIT(M541L) in five males(More)
Although, for homogeneous columns, the differences between Engesser's and Haringx's formulas for shear buckling have been explained in 1971 by the dependence of shear modulus on the axial stress, for soft-core sandwich columns the choice of the correct formula has baffled engineers for half a century. Recently, Bažant explained this difference by a(More)
The previous energetic variational analysis of critical loads and of the choice of finite strain measure for structures very weak in shear, remaining in a state of small strain, is extended to the initial postcritical behavior. For this purpose, consideration of the transverse deformation is found to be essential. It is shown that imperfection sensitivity(More)
Despite impressive advances, the existing constitutive and fracture models for fiber-reinforced concrete ͑FRC͒ are essentially limited to uniaxial loading. The microplane modeling approach, which has already been successful for concrete, rock, clay, sand, and foam, is shown capable of describing the nonlinear hardening–softening behavior and fracturing of(More)
Core Binding Factor acute myeloid leukemia (CBF-AML) with t(8;21) RUNX1-MTG8 or inv(16) CBFB-MYH11 fusion proteins often show upregulation of wild type or mutated KIT receptor. However, also non-CBF-AML frequently displays upregulated KIT expression. In the first part of this study we show that KIT expression can be also upregulated by miR-17, a regulator(More)