Alessandra Pinna

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BACKGROUND Microvascular insufficiency represents a major cause of end-organ failure among diabetics. METHODS AND RESULTS In streptozotocin-induced diabetic mice, we evaluated the potential of human tissue kallikrein (hTK) gene as a sole therapy against peripheral microangiopathy. Local delivery of hTK gene halted the progression of microvascular(More)
BACKGROUND Kinins are modulators of cardiovascular function. After ischemic injury, enhanced kinin generation may contribute in processes responsible for tissue healing. METHODS AND RESULTS Using pharmacological and genetic approaches, we investigated the role of kinin B(1) receptor in reparative angiogenesis in a murine model of limb ischemia. The effect(More)
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