Alessandra Pinna

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BACKGROUND Microvascular insufficiency represents a major cause of end-organ failure among diabetics. METHODS AND RESULTS In streptozotocin-induced diabetic mice, we evaluated the potential of human tissue kallikrein (hTK) gene as a sole therapy against peripheral microangiopathy. Local delivery of hTK gene halted the progression of microvascular(More)
  • Julie Spano, Lee Chao, Luigi Chao, Paolo Sciola, Costanza Madeddu, Maria B Emanueli +14 others
  • 2002
Background—Microvascular insufficiency represents a major cause of end-organ failure among diabetics. Methods and Results—In streptozotocin-induced diabetic mice, we evaluated the potential of human tissue kallikrein (hTK) gene as a sole therapy against peripheral microangiopathy. Local delivery of hTK gene halted the progression of microvascular(More)
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