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Truncation of amidated fragment 33-61 of bovine alpha-hemoglobin: effects on the structure and anticandidal activity.
It is reported that Hb33-61a is lethal to Candida albicans at 6.25 microM probably through disruption of its plasma membrane and it is hypothesized that these two structured regions, by fluctuating independently in the lipid environment, may act in a coordinated fashion disrupting the yeast plasma membrane. Expand
Synthesis and properties of cyclic gomesin and analogues
- Alessandra Machado, M. A. Fázio, A. Miranda, S. Daffre, M. T. Machini
- Chemistry, Medicine
- Journal of peptide science : an official…
- 1 September 2012
Because of its high therapeutic index, easy synthesis and lower cost, the [Thr2,6,11,15,d‐Pro9]‐Gm analogue remains the best active Gm‐derived AMP developed so far; nevertheless, its elevated instability in human serum may limit its therapeutic potential. Expand
Specific Sequences Determine the Stability and Cooperativity of Folding of the C-terminal Half of Tropomyosin*
- A. Paulucci, L. Hicks, Alessandra Machado, M. T. Miranda, C. Kay, C. Farah
- Chemistry, Medicine
- The Journal of Biological Chemistry
- 18 October 2002
A number of factors may contribute to this particular instability of tropomyosin, including an interhelix repulsion between g and e′ positions of the heptad repeat, a charged residue at the hydrophobic coiled-coil interface, and a greater fraction of β-branched residues located at d positions. Expand
The micelle-bound structure of an antimicrobial peptide derived from the alpha-chain of bovine hemoglobin isolated from the tick Boophilus microplus.
It is shown that the peptide Hb33-61a bound to SDS micelles exhibits a nonconventional conformation for an antimicrobial peptide, and is able to disrupt the bacterial membrane of Micrococcus luteus A270. Expand
Interactions of di-imine copper(II) complexes with albumin: competitive equilibria, promoted oxidative damage and DFT studies
Interactions of some diimine copper(II) complexes with bovine serum albumin (BSA) were investigated by spectroscopic techniques in order to compare the stability of the complexes and their capability… Expand