Alert Meyer-Spasche

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In mammals, the principal circadian pacemaker is housed in the hypothalamic suprachiasmatic nuclei (SCN). The SCN exhibit high levels of vasoactive intestinal polypeptide (VIP) immunoreactivity and two of the three VIP receptors, VPAC(2) and PAC(1), are found in the rat SCN. However, the role of VIP in the SCN remains unclear. In this study, we examined the(More)
The firing activity of suprachiasmatic nuclei (SCN) neurones in vitro shows a circadian rhythm with the peak in average firing frequency during the middle of the projected day. Vasoactive intestinal polypeptide (VIP), which is abundant in the rat SCN, phase-advances the time of peak in SCN neuronal activity when applied in vitro during the late projected(More)
The suprachiasmatic nuclei (SCN) of the hypothalamus house the main mammalian circadian pacemaker. Cell bodies in the rat SCN contain the neuropeptide neurotensin (NT), and two NT receptor types, NTS1 and nts2. Because the role of NT in the circadian rhythm processes is unknown, we studied the phase-shifting effects of NT on the firing rate rhythm of rat(More)
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