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  • Barbara L. Apostol, Katalin Illés, +8 authors Leslie M. Thompson
  • Biology, Medicine
  • Human molecular genetics
  • 2006 (First Publication: 15 January 2006)
  • Huntington's disease (HD) is a devastating neurodegenerative disorder caused by an expanded polyglutamine (polyQ) tract within the huntingtin protein (Htt). Identifying the pathways that are alteredExpand
  • Xiaoqian Zhang, Donna Lee Smith, +13 authors Aleksey G. Kazantsev
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 2005 (First Publication: 18 January 2005)
  • Polyglutamine (polyQ) disorders, including Huntington's disease (HD), are caused by expansion of polyQ-encoding repeats within otherwise unrelated gene products. In polyQ diseases, the pathology andExpand
  • Ruth A Bodner, Tiago Fleming Outeiro, +7 authors Aleksey G. Kazantsev
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 2006 (First Publication: 14 March 2006)
  • Misfolded proteins accumulate in many neurodegenerative diseases, including huntingtin in Huntington's disease and alpha-synuclein in Parkinson's disease. The disease-causing proteins can takeExpand