Aleksey A. Suvorov

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Effects of Cd2+ and two complexes of bivalent cadmium with 1,3-bis(4-chlorbenzylidenamino)-guanidine and anabasine on ion permeability of the inner membrane and respiration of isolated rat liver mitochondria were studied. Starting from 5 microM, Cd2+ decreased state 3 and DNP-stimulated respiration of mitochondria and increased their state 4 respiration. At(More)
27 Among physiologically active compounds of plant origin, isoquinoline alkaloids occupy a special place [1, 2]. Currently, an increased interest to these compounds is associated with the search for alternative ways of obtaining medically important morphines from plants of the family Papaver (in particular, from the poppy Papaver bracteatum Lindl.), which(More)
Comparative study was performed of action of a group of 15 isoquinoline homoproaporphine and homoaporphine alkaloids, 10 tropolone colchicine alkaloids and their lumoderivatives that were isolated from corms of a representative of the lily family, the showy autumn crocus Colchicum speciosum Stev. on activity of mammalian erythrocyte acetylcholinesterase and(More)
The amino acid sequences of several dozens of cholinesterases of vertebrates and invertebrates are known [1]. Despite certain structural differences, all of them have essentially the same composition of functionally important fragments of the active sites. The latter contain the main elements of the catalytic mechanism, i.e., the catalytic triad (serine,(More)
The review deals with study of enzymologic properties of a novel highly specific acetylcholinesterase substrate, N-(β-acetoxyethyl) piperidinium iodomethylate (“piperidylcholine”), and its 30 derivatives that were tested as effectors of cholinesterases of mammals and various species of Pacific squids. It was proven for the first time that responsible for(More)
An analysis of influence of indophenol substrate structure on rate of their enzymatic hydrolysis under action of cholinesterases (ChE) of different animals is carried out for the first time. Study of indophenylacetate (IPhA) and a group of isomeric dichloroderivatives as substrates of erythrocyte acetylcholinesterase, serum butyrylcholinesterase, and ChE(More)
Literature data are summarized on cholinesterases of some mammals and arthropods with a group of isomer derivatives of alkaloid lupinin and its epimer epilupinin. As substrates of cholinesterases of some mammals there are studied 8 acetates containing in their molecule chinolysidin bicycle with different structure of N-alkyl radical, which showed certain(More)
218 The problem of search for specific effectors (substrates and reversible and irreversible inhibitors) was and remains a topical problem in studies of large and diverse enzyme families, such as the cholinesterase family [1, 2]. The specific substrates for two reference cholinesterases—human erythrocyte acetylcholinesterase (EC 3.1.1.7) and horse blood(More)