Aleksandra V Zinchenko

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The binding of proflavine to calf thymus DNA has been studied using the methods of differential scanning calorimetry and spectrophotometry. It was shown that proflavine can interact with DNA by at least 3 binding modes. At high DNA-ligand concentration ratios (P/D), proflavine intercalates into both GC- and AT-sites, with a preference to GC-rich sequences.(More)
The dynamic phase diagrams of the water-ethylene glycol (EG) system have been plotted at the warming rate of 0.4 degrees C/min(-1) after cooling of samples down to -196 degrees C by quenching in liquid nitrogen or slow cooling at the rate of approximately 0.15 degrees C/min(-1). The melting of two stable eutectics at the temperatures of -42.7 degrees C and(More)
BACKGROUND Critical to the understanding the mechanism of destruction and protection during cryopreservation of biological objects is the knowledge of the conformational transitions of biopolymers experiencing low temperatures in the presence of cryoprotective agents. This information may be derived from the kinetic and thermodynamic parameters of(More)
The object of this research is to study acoustic emissions (AE) in aqueous solutions of polyethylene glycols (PEGs) of molecular masses from 300 to 3000 during cooling at 100 degrees C/min and heating at 70 degrees C/min in the temperature range from 0 to -196 degrees C. The dependence of AE intensity on PEG concentration and molecular mass is analysed. The(More)
The effect of freezing regimes and storage temperatures on protein conformation and the spectrum of cord blood serum has been investigated. Changes in the parameters of ESR spectra of spin probes in cord blood serum after slow freezing and subsequent thawing were established, indicating protein conformational changes characterized by loosening. This fact is(More)
BACKGROUND Cryopreservation of mesenchymal stromal cells (MSCs) and MSCs-based tissue engineered constructs (TECs) is a promising strategy for regenerative medicine. OBJECTIVE To examine vitrification system consisting of multicomponent vitreous solution, closed type container, human adult MSCs and two-step exposure procedure as a platform for(More)
The interaction of actinocin derivative Act III with single- and double-stranded poly(rC) has been investigated by the methods of differential scanning microcalorimetry and UV-vis absorption spectroscopy. It was shown that, after the addition of the ligand, the temperature, enthalpy and entropy of poly (rC) melting decrease. The analysis of poly(rC)-ActIII(More)