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  • Peter J. Kilford, Rowan A Stringer, Bindi Sohal, Joseph B. Houston, Aleksandra Galetin
  • Chemistry, Medicine
  • Drug Metabolism and Disposition
  • 2009 (First Publication: 1 January 2009)
  • Glucuronidation via UDP-glucuronosyltransferase (UGT) is an increasingly important clearance pathway. In this study intrinsic clearance (CLint) values for buprenorphine, carvedilol, codeine,Expand
  • Verawan Uchaipichat, Peter I. Mackenzie, +4 authors John O. Miners
  • Chemistry, Medicine
  • Drug metabolism and disposition: the biological…
  • 2004 (First Publication: 1 April 2004)
  • The glucuronidation kinetics of the prototypic substrates 4-methylumbelliferone (4MU) and 1-naphthol (1NP) by human UDP-glucuronosyltransferases (UGT) 1A1, 1A3, 1A4, 1A6, 1A7, 1A8, 1A9, 1A10, 2B7,Expand
  • Hayley S. Brown, Kiyomi Ito, Aleksandra Galetin, Joseph B. Houston
  • Medicine, Chemistry
  • British journal of clinical pharmacology
  • 2005 (First Publication: 1 November 2005)
  • AIMS Success of the quantitative prediction of drug-drug interactions via inhibition of CYP-mediated metabolism from the inhibitor concentration at the enzyme active site ([I]) and the in vitroExpand
  • Michael Gertz, Anthony F. Harrison, Joseph B. Houston, Aleksandra Galetin
  • Medicine, Chemistry
  • Drug Metabolism and Disposition
  • 2010 (First Publication: 1 July 2010)
  • Intestinal first-pass metabolism may contribute to low oral drug bioavailability and drug-drug interactions, particularly for CYP3A substrates. The current analysis predicted intestinal availabilityExpand
  • Aleksandra Galetin, Howard J. Burt, Laura E Gibbons, Joseph B. Houston
  • Medicine, Chemistry
  • Drug Metabolism and Disposition
  • 2006 (First Publication: 1 January 2006)
  • Time-dependent inhibition of CYP3A4 often results in clinically significant drug-drug interactions. In the current study, 37 in vivo cases of irreversible inhibition were collated, focusing onExpand
  • Hannah M. Jones, H. Arnold Barton, +8 authors Katherine S. Fenner
  • Medicine, Chemistry
  • Drug Metabolism and Disposition
  • 2012 (First Publication: 1 May 2012)
  • With efforts to reduce cytochrome P450-mediated clearance (CL) during the early stages of drug discovery, transporter-mediated CL mechanisms are becoming more prevalent. However, the prediction ofExpand
  • Peter J. Kilford, Michael Gertz, Joseph B. Houston, Aleksandra Galetin
  • Chemistry, Medicine
  • Drug Metabolism and Disposition
  • 2008 (First Publication: 1 July 2008)
  • Analogous to the fraction unbound in microsomes (fumic), fraction unbound in hepatocyte incubations (fuhep) is an important parameter in the prediction of intrinsic clearance and potential drug-drugExpand