Aleksandra Bryzek

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Non-differentiated cells are attractive targets for cell therapy. During liver regeneration oval cells intensively proliferate and differentiate extending their metabolic activity. Hepatic cytochromes P450 (CYPs) can be linked either with metabolic activation of toxic compounds or drug metabolism. We investigated the differentiation and biotransformative(More)
It has been established beyond doubt that, as well as the liver, the small intestine is an important site of first-pass metabolism of numerous drugs, food components and toxic xenobiotics. However, there is not much information available about age-dependent changes of intestinal biotransformation pathways. In the present paper, we evaluated the(More)
1 Almoreksant, antagonista receptorów oreksynergicznych mózgu w leczeniu zaburzeń snu Almorexant, an antagonist of the brain orexinergic receptors in the therapy of sleep disorders Summary The sleep disturbances are at present a serious medical and social problems. The inappropriate pharmacotherapy of insomnia may be dangerous to health and apart from that(More)
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