Aleksander Sadikov

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We recently found that DNA methylation of S100A2, spleen tyrosine kinase (SYK), and Stathmin-1 (STMN1) correlates with response to tamoxifen therapy in metastatic breast cancer. In this retrospective study, we investigated immunohistochemically whether these three markers are predictors of relapse in early breast cancer (EBC) patients treated with adjuvant(More)
INTRODUCTION The excision repair cross-complementing 1 (ERCC1) protein is an extensively investigated molecular marker because it may decrease sensitivity to platinum-based chemotherapy. Low ERCC1 expression has already been correlated with better treatment efficacy in non-small-cell lung cancer patients treated with platinum-based chemotherapy. However,(More)
BACKGROUND The brain represents a frequent progression site in lung adenocarcinoma. This study was designed to analyse the association between the epidermal growth factor receptor (EGFR) mutation status and the frequency of brain metastases (BM) and survival in routine clinical practice. PATIENTS AND METHODS We retrospectively analysed the medical records(More)
Knowledge elicitation is known to be a difficult task and thus a major bottleneck in building a knowledge base. Machine learning has long ago been proposed as a way to alleviate this problem. Machine learning usually helps the domain expert to uncover some of the more tacit concepts. However, the learned concepts are often hard to understand and hard to(More)
A challenge for the clinical management of advanced Parkinson's disease (PD) patients is the emergence of fluctuations in motor performance, which represents a significant source of disability during activities of daily living of the patients. There is a lack of objective measurement of treatment effects for in-clinic and at-home use that can provide an(More)
BACKGROUND There are concerns about growing barriers to cancer research. We explored the characteristics of and barriers to global clinical cancer research. METHODS The American Society of Clinical Oncology International Affairs Committee invited 300 selected oncologists with research experience from 25 countries to complete a Web-based survey. Fisher's(More)
This paper describes our approach to the task 1 of the ECML PKDD 2011 VideoLectures.Net Recommender System Challenge. The task was to select a set of lectures to be recommended to a visitor of the VideoLecture.Net homepage after already seeing another lecture. Our proposed approach is a hybrid recommender system combining content and collaborative(More)
BACKGROUND Activating mutations in the epidermal growth factor (EGFR) gene confer sensitivity to the tyrosine kinase inhibitors (TKIs) in patients with advanced non-small cell lung cancer (NSCLC). TKI treatment efficacy and EGFR mutation implications were evaluated in clinically selected advanced NSCLC patients treated with TKIs in routine clinical(More)
Urokinase-type plasminogen activator (uPA) and its main inhibitor (PAI-1) were shown with level 1 evidence to be prognostic factors for primary breast cancer. Our preliminary retrospective study on a cohort of 1,220 consecutive patients hinted that uPA and PAI-1 could also serve as predictive factors for systemic therapy, namely that patients with high(More)