Aleksandar Sabljic

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The molecular connectivity indices (MCIs) have been successfully used for over 20 years in quantitative structure activity relationships (QSAR) modelling in various areas of physics, chemistry, biology, drug design, and environmental sciences. With this review, we hope to assist present and future QSAR practitioners to apply MCIs more wisely and more(More)
Several recent studies have shown that n-octanol/water partition coefficients may not be a good predictor for estimating soil sorption coefficients of persistent organic pollutants (POPs), defined here as chemicals with log Kow greater than 5. Thus, an alternative QSAR model was developed that seems to provide reliable estimates for the soil sorption(More)
  • A Sabljić
  • 1991
The experimental determination of environmental parameters (e.g. soil sorption, bioconcentration, biodegradation and biotransformation, toxic effects, etc.) of commercial chemicals is a costly and time-consuming process. Since there is a large number of chemicals currently in common use (approximately 100,000) and new chemicals are registered at a very high(More)
For the majority of commercial chemicals present in the troposphere, the reaction with OH radicals during the day and with NO3 radicals at night are the most important abiotic pathways for their degradation and removal from the troposphere. Today, there are only a couple of methods available for estimating the reactivity of commercial chemicals with(More)
Experimentally determining soil sorption behavior of xenobiotic chemicals during the last 10 years has been costly, time-consuming, and very tedious. Since an estimated 100,000 chemicals are currently in common use and new chemicals are registered at a rate of 1000 per year, it is obvious that our human and material resources are insufficient to(More)
Bioconcentration factor (BCF) is the concentration of a chemical in an organism divided by the concentration in water and it is one of the most important indicators for the fate of chemicals in the environment. Present methods for a preliminary estimation of concentration of hazardous chemicals in biota are based on empirical parameters, like water(More)
It is often presumed that all chemicals in soil are available to microorganisms, plant roots, and soil fauna via dermal exposure. Subsequent bioaccumulation through the food chain may then result in exposure to higher organisms. Using the presumption of total availability, national governments reduce environmental threshold levels of regulated chemicals by(More)