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Recruitment of Parvalbumin-Positive Interneurons Determines Hippocampal Function and Associated Behavior
TLDR
The effects of insufficient recruitment of fast-spiking cells at the network and behavioral level are shown and the role of this subpopulation for working and episodic-like memory is demonstrated. Expand
Select Overexpression of Homer1a in Dorsal Hippocampus Impairs Spatial Working Memory
TLDR
It is reported that sustained overexpression of H1aV impaired spatial working but not reference memory, and impairments generated by sustained high Homer1a levels identify a requirement for long Homer forms in synaptic plasticity and temporal encoding of spatial memory. Expand
Muskelin Regulates Actin Filament- and Microtubule-Based GABAA Receptor Transport in Neurons
TLDR
The concept that specific trafficking factors help cargoes to traverse both F-actin and microtubule compartments, thereby regulating their fate is suggested, which suggests muskelin transport functions beyond neurons. Expand
Recruitment of oriens-lacunosum-moleculare interneurons during hippocampal ripples
TLDR
The authors' data unveil recruitment of O-LM neurons during ripples, suggesting a previously uncharacterized role of this cell type during sharp wave-associated activity. Expand
Homer1 gene products orchestrate Ca2+-permeable AMPA receptor distribution and LTP expression
TLDR
Homer1a is essential for the activity-dependent regulation of excitatory synaptic transmission and deletion of Homer1 enhanced the AMPAR-mediated component of glutamatergic currents at Schaffer collateral synapses as demonstrated by increased AMPA/NMDA current ratios. Expand
The function of glutamatergic synapses is not perturbed by severe knockdown of 4.1N and 4.1G expression
TLDR
This study indicates that 4.1G and4.1N do not have a crucial role in glutamatergic synaptic transmission and the induction and maintenance of long-term plastic changes in synaptic efficacy. Expand
Soluble TREM-1 as a diagnostic and prognostic biomarker in patients with septic shock: an observational clinical study
TLDR
Plasma levels of sTREM-1 were found to identify patients with septic shock more effectively than procalcitonin and C-reactive protein and was identified to be an early predictor for survival in patients withSepsis syndrome. Expand
Cell-Type-Specific Modulation of Feedback Inhibition by Serotonin in the Hippocampus
TLDR
Serotonin via 5-HT1B heteroreceptors substantially reduces synaptic excitation of cholecystokinin-expressing interneurons in area CA1 of the rat hippocampus, in contrast to parvalbumin- expressing basket cells, implying an important role for serotonergic modulation of GABAergic action in subcortical control of hippocampal output. Expand
Reduced Serum Butyrylcholinesterase Activity Indicates Severe Systemic Inflammation in Critically Ill Patients
TLDR
It is shown here that the reduced BChE activity associated with systemic inflammation occurs independently of and is thus not caused by any deficit in liver function in patients with severe systemic inflammation. Expand
Reduced butyrylcholinesterase activity is an early indicator of trauma-induced acute systemic inflammatory response
TLDR
This study suggests that the BChE activity reduction might serve as an early indicator of acute systemic inflammation, and might play an important role in the early diagnosis of the trauma-induced systemic inflammation. Expand
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