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Several agents that are preferential T-type calcium (T-channel) blockers have shown promise as being effective in alleviating acute and chronic pain, suggesting an urgent need to identify even more selective and potent T-channel antagonists. We used small, acutely dissociated dorsal root ganglion (DRG) cells of adult rats to study the in vitro effects of(More)
We recently showed that streptozotocin (STZ) injections in rats lead to the development of painful peripheral diabetic neuropathy (PDN) accompanied by enhancement of CaV3.2 T-type calcium currents (T-currents) and hyperexcitability in dorsal root ganglion (DRG) neurons. Here we used the classical peripherally acting T-channel blocker mibefradil to examine(More)
BACKGROUND Peripheral nerve injuries may result in debilitating pain that is poorly responsive to conventional treatment. Neuropathic pain induced by peripheral nerve injury is caused, in part, by ectopic discharges from the injury site or the dorsal root ganglia (DRG) resulting in enhanced central input and central hyperexcitability. A heterogeneous family(More)
Open Mobile Alliance Device Management (OMA DM) specification is well established and is being widely used to manage mobile devices. However, the current OMA DM protocol (v1.2 and v1.3) is not suitable for constrained M2M devices operating in constrained networks. Therefore, new standards for M2M technology are being developed in order to sustain the(More)
BACKGROUND Neuropathic pain (NPP) is likely the result of repetitive high-frequency bursts of peripheral afferent activity leading to long-lasting changes in synaptic plasticity in the spinal dorsal horn. Drugs that promote γ-aminobutyric acid (GABA) activity in the dorsal horn provide partial relief of neuropathic symptoms. The authors examined how in vivo(More)
In this paper, a stability test procedure is proposed for perturbed nonlinear nonhomogeneous fractional order systems with a pure time delay. Sufficient conditions of this kind of stability are derived for particular class of fractional time-delay systems using generalized Gronwall inequality. A numerical example is given to illustrate the validity of the(More)
This paper suggests a new optimal control of robotic system based on a biologically inspired control principle-synergy, which allows resolving actuator redundancy. The redundancy control problem has been discussed in the framework of optimal control problem which is solved by Pontryagin's maximum principle. Joint actuator synergy approach is suggested which(More)
The major aim of this paper is to promote a biologically inspired control synergy approach that allows the resolution of redundancy of a given robotized system which can be used for military purposes. It is shown that it is possible to resolve kinematic redundancy using the local optimization method and biological analogues – control synergy approach,(More)
A paradigm in transplantation states that graft-infiltrating T cells are largely non-alloreactive "bystander" cells. However, the origin and specificity of allograft T cells over time has not been investigated in detail in animals or humans. Here, we use polychromatic flow cytometry and high throughput TCR sequencing of serial biopsies to show that(More)
We examined tolerance mechanisms in patients receiving HLA-mismatched combined kidney-bone marrow transplantation (CKBMT) that led to transient chimerism under a previously published nonmyeloablative conditioning regimen (Immune Tolerance Network study 036). Polychromatic flow cytometry and high-throughput sequencing of T cell receptor-β hypervariable(More)