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The Mutational Landscape of Head and Neck Squamous Cell Carcinoma
The mutational profile of head and neck cancer is complex and may pose challenges to the development of targeted therapies. Head and neck squamous cell carcinoma (HNSCC) is a common, morbid, andExpand
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The treatment-naive microbiome in new-onset Crohn's disease.
Inflammatory bowel diseases (IBDs), including Crohn's disease (CD), are genetically linked to host pathways that implicate an underlying role for aberrant immune responses to intestinal microbiota.Expand
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Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment.
Increasing evidence links the gut microbiota with colorectal cancer. Metagenomic analyses indicate that symbiotic Fusobacterium spp. are associated with human colorectal carcinoma, but whether thisExpand
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Genomic analysis identifies association of Fusobacterium with colorectal carcinoma.
The tumor microenvironment of colorectal carcinoma is a complex community of genomically altered cancer cells, nonneoplastic cells, and a diverse collection of microorganisms. Each of theseExpand
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The microbiome in inflammatory bowel disease: current status and the future ahead.
Studies of the roles of microbial communities in the development of inflammatory bowel disease (IBD) have reached an important milestone. A decade of genome-wide association studies and other geneticExpand
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The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetes.
Colonization of the fetal and infant gut microbiome results in dynamic changes in diversity, which can impact disease susceptibility. To examine the relationship between human gut microbiome dynamicsExpand
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Prognostically relevant gene signatures of high-grade serous ovarian carcinoma.
Because of the high risk of recurrence in high-grade serous ovarian carcinoma (HGS-OvCa), the development of outcome predictors could be valuable for patient stratification. Using the catalog of TheExpand
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Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans
transplant recipients with additional estrogen did not add any additional protective effects. Next, the authors tested if their experimental data were also reflected by clinical findings. In aExpand
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Fusobacterium nucleatum in colorectal carcinoma tissue and patient prognosis
Objective Accumulating evidence links the intestinal microbiota and colorectal carcinogenesis. Fusobacterium nucleatum may promote colorectal tumour growth and inhibit T cell-mediated immuneExpand
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PathSeq: software to identify or discover microbes by deep sequencing of human tissue
Many human diseases are believed to be caused by undiscovered pathogens1–3. The advent of next-generation sequencing technology presents an unprecedented opportunity to identify pathogens in hithertoExpand
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