Alejandro Sánchez Alvarado

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Multicellular organisms possessing relatively long life spans are subjected to diverse, constant, and often intense intrinsic and extrinsic challenges to their survival. Animal and plant tissues wear out as part of normal physiological functions and can be lost to predators, disease, and injury. Both kingdoms survive this wide variety of insults by(More)
The planarian Schmidtea mediterranea is rapidly emerging as a model organism for the study of regeneration, tissue homeostasis and stem cell biology. The recent sequencing, assembly and annotation of its genome are expected to further buoy the biomedical importance of this organism. In order to make the extensive data associated with the genome sequence(More)
What do Charles Darwin and the dancer Isadora Duncan have in common? Apparently, they shared and deeply admired a mutual friend: the German biologist Ernst Haeckel. A towering figure in the intellectual and scientific circles of the late 19 th and early 20 th century, Haeckel's name has been relegated to the shadows of modern thought. In fact, when the name(More)
Cell differentiation is an essential process for the development, growth, reproduction, and longevity of all multicellular organisms, and its regulation has been the focus of intense investigation for the past four decades. The study of natural and induced stem cells has ushered an age of re-examination of what it means to be a stem or a differentiated(More)
Technological advances in biology have begun to dramatically change the way we think about evolution, development, health and disease. The ability to sequence the genomes of many individuals within a population, and across multiple species, has opened the door to the possibility of answering some long-standing and perplexing questions about our own genetic(More)
Freshwater planarians are best known for their ability to regenerate complete animals from tiny fragments of their bodies. This regenerative ability is based upon totipotent, somatic stem cells present in the adult planarian. Planarians are free-living representatives of the Platyhelminthes, an understudied yet evolutionarily and clinically important(More)
BACKGROUND Head or anterior body part regeneration is commonly associated with protostome, but not deuterostome invertebrates. However, it has been shown that the solitary hemichordate Ptychodera flava possesses the remarkable capacity to regenerate their entire nervous system, including their dorsal neural tube and their anterior head-like structure, or(More)
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