Alejandro Ivan Hernandez

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Early Alzheimer's disease (AD) pathophysiology is characterized by synaptic changes induced by degradation products of amyloid precursor protein (APP). The exact mechanisms of such modulation are unknown. Here, we report that nanomolar concentrations of intraaxonal oligomeric (o)Abeta42, but not oAbeta40 or extracellular oAbeta42, acutely inhibited synaptic(More)
Protein kinase Mzeta (PKMzeta) is an atypical protein kinase C isoform that has been implicated in the protein synthesis-dependent maintenance of long term potentiation and memory storage in the brain. Synapse-associated kinases are uniquely positioned to promote enduring consolidation of structural and functional modifications at the synapse, provided that(More)
— In this paper we describe our ongoing work on the control of a tendon driven robotic hand by an adaptive learning mechanism evolved using a simulator developed over the last years. The proposed neural network allows the robotic hand to explore its own movement possibilities to interact with objects of different shape, size and material and learn how to(More)
Early Alzheimer's disease (AD) pathophysiology is characterized by synaptic changes induced by degradation products of amyloid precursor protein (APP). The exact mechanisms of such modulation are unknown. Here, we report that nanomolar concentrations of intraaxonal oligomeric (o)A␤42, but not oA␤40 or extracellular oA␤42, acutely inhibited synaptic(More)
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