Alejandro González

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BACKGROUND In recent years Galaxy has become a popular workflow management system in bioinformatics, due to its ease of installation, use and extension. The availability of Semantic Web-oriented tools in Galaxy, however, is limited. This is also the case for Semantic Web Services such as those provided by the SADI project, i.e. services that consume and(More)
BACKGROUND Two distinct trends are emerging with respect to how data is shared, collected, and analyzed within the bioinformatics community. First, Linked Data, exposed as SPARQL endpoints, promises to make data easier to collect and integrate by moving towards the harmonization of data syntax, descriptive vocabularies, and identifiers, as well as providing(More)
— Center of mass (CoM) trajectory is important during standing and walking since it can be used as an index for stability and fall prediction. Unfortunately current methods for CoM estimation require the use of specialized equipment (such as motion capture and force platforms) in controlled environments. This paper aims at applying the statically equivalent(More)
— A human's center of mass (CoM) trajectory is useful to evaluate the dynamic stability during daily life activities such as walking and standing up. To estimate the subject-specific CoM position in the home environment, we make use of a statically equivalent serial chain (SESC) developed with a portable measurement system. In this paper we implement a(More)
—Center of mass (CoM) estimation can be used to evaluate human stability during rehabilitation. A personalized estimation can be obtained using the serial equivalent static chain (SESC) method, calibrated using a series of static postures. The estimation accuracy is dependent on the number and quality of poses used during calibration. Currently, this limits(More)
BACKGROUND Biomedical ontologies are key elements for building up the Life Sciences Semantic Web. Reusing and building biomedical ontologies requires flexible and versatile tools to manipulate them efficiently, in particular for enriching their axiomatic content. The Ontology Pre Processor Language (OPPL) is an OWL-based language for automating the changes(More)
Cardiovascular disease is the leading cause of morbidity and mortality in the industrialized world. Familial aggregation of cardiovascular risk factors is a frequent finding, but genetic factors affecting its presentation are still poorly understood. The calpain 10 gene (CAPN10) has been associated with type 2 diabetes (T2DM), a complex metabolic disorder(More)
The most relevant modules of a pedestrian detector are the candidate generation and the candidate classification. The former aims at presenting image windows to the latter so that they are classified as containing a pedestrian or not. Much attention has being paid to the classification module, while candidate generation has mainly relied on (multiscale)(More)
BACKGROUND Genes implicated in common complex disorders such as obesity, type 2 diabetes mellitus (T2DM) or cardiovascular diseases are not disease specific, since clinically related disorders also share genetic components. Cysteine protease Calpain 10 (CAPN10) has been associated with T2DM, hypertension, hypercholesterolemia, increased body mass index(More)