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  • Walter W. Shuford, Kerry Klussman, +11 authors Robert S. Mittler
  • Biology, Medicine
  • The Journal of experimental medicine
  • 1997 (First Publication: 7 July 1997)
  • The 4-1BB receptor is an inducible type I membrane protein and member of the tumor necrosis factor receptor (TNFR) superfamily that is rapidly expressed on the surface of CD4+ and CD8+ T cells afterExpand
  • W Conrad Liles, Peter A. Kiener, Jeffrey A. Ledbetter, Alejandro Aruffo, Seymour J. Klebanoff
  • Medicine, Biology
  • The Journal of experimental medicine
  • 1996 (First Publication: 1 August 1996)
  • Human neutrophils, monocytes, and eosinophils are known to undergo apoptotic cell death. The Fas/Fas ligand pathway has been implicated as an important cellular pathway mediating apoptosis in diverseExpand
  • Peter S. Linsley, William Patrick Brady, Laura Sue Grosmaire, Alejandro Aruffo, Nitin K. Damle, Jeffrey A. Ledbetter
  • Medicine, Biology
  • The Journal of experimental medicine
  • 1991 (First Publication: 1 March 1991)
  • A successful immune response requires intercellular contact between T and B lymphocytes. We recently showed that CD28, a T cell surface protein that regulates an activation pathway, could mediateExpand
  • Randolph J. Noelle, María Elena Romero Roy, David M Shepherd, Ivan Stamenković, Jeffrey A. Ledbetter, Alejandro Aruffo
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1992 (First Publication: 15 July 1992)
  • CD40 is a B-cell surface molecule that has been shown to induce B-cell growth upon ligation with monoclonal antibodies. This report shows that triggering via CD40 is essential for the activation ofExpand
  • Juan J. Pérez-Villar, Gena S. Whitney, M. A. Bowen, Derek Hewgill, Alejandro Aruffo, Steven B. Kanner
  • Biology, Medicine
  • Molecular and Cellular Biology
  • 1999 (First Publication: 1 April 1999)
  • ABSTRACT The negative regulation of T- or B-cell antigen receptor signaling by CD5 was proposed based on studies of thymocytes and peritoneal B-1a cells from CD5-deficient mice. Here, we show thatExpand