Alejandra Ragone

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Background:Germline mutations in BRCA1 and BRCA2 predispose to pancreatic cancer. We estimated the incidence of pancreatic cancer in a cohort of female carriers of BRCA1 and BRCA2 mutation. We also estimated survival rates in pancreatic cancer cases from families with a BRCA mutation.Methods:We followed 5149 women with a mutation for new cases of pancreatic(More)
Background:Germline mutations in BRCA1 and BRCA2 increase the susceptibility to develop breast and ovarian cancers as well as increase the risk of some other cancers. Primary objective was to estimate the risk of leukaemia in BRCA1 and BRCA2 mutation carriers.Methods:We followed 7243 women with a BRCA1 or a BRCA2 mutation for incident cases of leukaemia. We(More)
OBJECTIVE To describe the long-term outcomes of pediatric pleural empyema. DESIGN Prospective observational study from October 2008 to October 2011. SETTING Tertiary care children's hospital. PARTICIPANTS Children with pleural empyema (loculations and/or septations identified on radiologic imaging or frank pus on thoracentesis). MAIN OUTCOME(More)
OBJECTIVE To compare secular trends in the age representation of published randomized controlled trials (RCTs) in specialty journals during a period of 20 years. DATA SOURCE A validated electronic search strategy using Ovid MEDLINE was conducted to identify RCTs published in the years 1985 through 2005. STUDY SELECTION The publications retrieved were(More)
BACKGROUND Medication errors are common in the pediatric outpatient setting, and children with multiple prescriptions are at increased risk. Little is known about medication reconciliation's application in the ambulatory setting. Caregivers' perceptions of a patient medication list (PML), created for children with complex health needs, were assessed. (More)
Spirometry plays an important role in occupational respiratory health surveillance programs. However, when not performed correctly, the values obtained can be misleading, resulting in misclassification of the workers' health status. Studies carried out in Italy have shown that spirometries recorded by occupational physicians often do not comply with quality(More)
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