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The use of antagonists of the mineralocorticoid receptor in the treatment of myocardial hypertrophy and heart failure has gained increasing importance in the last years. The cardiac Na(+)/H(+) exchanger (NHE-1) upregulation induced by aldosterone could account for the genesis of these pathologies. We tested whether aldosterone-induced NHE-1 stimulation(More)
A field experiment was carried out over three seasons on Vitis vinifera cv. Tempranillo in order to compare pre-veraison and post-veraison water restrictions on vine performance and fruit composition. Rain-fed vines were compared with a treatment named MAX that was constantly irrigated at 75 % of the estimated crop evapotranspiration (ETc). In addition, an(More)
The beneficial effect of phosphodiesterase 5A inhibition in ischemia/reperfusion injury and cardiac hypertrophy is well established. Inhibition of the cardiac Na(+)/H(+) exchanger (NHE-1) exerts beneficial effects on these same conditions, and a possible link between these therapeutic strategies was suggested. Experiments were performed in isolated cat(More)
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