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Alternate geometries of a commercial dry powder inhaler (DPI, i.e., Turbuhaler; AstraZeneca, London, UK) are proposed based on the simulation results obtained from a fluid and particle dynamic… (More)
In the present study, an experimental and theoretical investigation on the nasal vaccine delivery is reported. Poly(lactide-co-glycolide) (PLGA) nanoparticles (NPs) containing a model antigen, i.e.,… (More)
Central nervous system (CNS) disorders (e.g., multiple sclerosis, Alzheimer's disease, etc.) represent a growing public health issue, primarily due to the increased life expectancy and the aging… (More)
Abstract The present work describes an integrated CFD model of the respiratory system from the nasal cavity down to the bronchioli. The model is comprised of nine sequential computational blocks… (More)
Abstract The present work describes an integrated CFD model of blood flow through a treated popliteal artery aneurism. The model is comprised of the treated region. Steady-state laminar and… (More)
Abstract A process systems approach towards the development and integration of computational models to describe the application, adhesion, spreading, and stability of a reacting hyaluronic acid gel… (More)