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Coppen A. The biochemistry of the affective disorders. This paper was a review of investigations into the role of neurotransmitters, endocrine factors and electrolytes in the aetiology and treatment of depressive and manic illness. [The Science Citation Index ® (SCI) and the Social Sciences Citation Index™ (SSCI™) indicate that this paper was cited a total(More)
Thirty-two patients who had responded to amitriptyline (150 mg daily) when suffering from a depressive illness were allocated either to receive placebo or to remain on the same medication for one year. Plasma concentrations of the drug were regularly estimated. There was no correlation between plasma concentration and subsequent residual affective(More)
Electrodermal activity was measured in a group of depressive patients and normal controls. Those patients classified as endogenous on the Newcastle Scale had significantly lower skin conductance levels than either the non-endogenous patients or controls. The endogenous depressives also contained significantly more non-responders to the experimental stimuli.(More)
We review the findings in major depression of a low plasma and particularly red cell folate, but also of low vitamin B12 status. Both low folate and low vitamin B12 status have been found in studies of depressive patients, and an association between depression and low levels of the two vitamins is found in studies of the general population. Low plasma or(More)
Reduced plasma, serum, or red blood cell folate is commonly found in major depressive illnesses. Supplementing antidepressant medication with folic acid enhances the therapeutic effect. Although more work is required to confirm these beneficial results, it is suggested that, meanwhile, 2 mg of folic acid should be given during the acute, continuation, and(More)
The authors review the literature in an attempt to evaluate the relationship between serotonin and depression. Animal studies show that the administration of tryptophan (the precursor of serotonin) increased serotonin synthesis and influenced behavior. Low plasma tryptophan levels have been found in patients with endogeneous depression. Postmortem studies(More)
  • A Coppen
  • 1994
In 1971, my colleagues and I published the first prospective double-blind trial of the prophylactic effect of lithium in patients suffering from both unipolar and bipolar illness. In this trial we found that patients who received lithium experienced significantly less morbidity and required significantly less additional antidepressant and antimanic(More)
In 107 patients on long-term lithium, those with lower plasma folate concentration had a higher affective morbidity than those with higher folate, both at the time and during the previous two years. The association was not the results of weight change or the concomitant use of other drugs. Animal work reporting a decreased synthesis of 5-HT both in(More)
The prevalence of an abnormal response to the dexamethasone suppression test (DST) was examined in 119 in-patients suffering from a major depressive disorder and in 79 normal controls. Only 11 per cent of controls showed an abnormal DST as against 70 per cent of depressed patients. The specificity of the DST was examined by testing patients with other(More)