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The inner ear develops from a simple ectodermal thickening known as the otic placode. Classic embryological manipulations rotating the prospective placode tissue found that the anteroposterior axis was determined before the dorsoventral axis. A small percentage of such rotations also resulted in the formation of mirror duplicated ears, or enantiomorphs. We(More)
The Gist specification language emerged at USC/ISI from more than five years of research into the development of operational specification languages and environments. We designed and implemented a Gist processor through extensive utilization of language development tools and a relational database management system available in a UNIX environment. We(More)
BACKGROUND The inner ear develops from an ectodermal thickening known as the otic placode into a complex structure that is asymmetrical along both the anterior-posterior (A-P) and dorsal-ventral (D-V) axes. Embryological manipulations in Xenopus allow us to test regenerative potential along specific axes and timing of axis determination. We explore the role(More)
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