Aldo Casaleggio

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The new generation of Implantable Cardioverter Defibrillators (ICDs) allows storage of intracardiac electrograms (EGMs) recorded immediately before the onset of malignant ventricular tachyarrhythmias (VTs) and during their course. Although all devices base most of diagnostic parameters on the bipolar EGMs, some of them allow two types of EGM recordings:(More)
Heart rate variability signals obtained from 24 h recordings are analyzed for normal and pathological subjects. This time series contains information about the autonomic nervous system action regulating the beat-to-beat heart rate. Nonlinear contributions to the long period variability have been assessed by the calculation of the entire spectrum of Lyapunov(More)
Implantable cardioverter defibrillators (ICDs) can store intracardiac electrograms (EGMs) in sinus rhythm (SR), at the onset of spontaneous ventricular tachyarrhythmias (VT) or during their course. This allows the investigation of unknown features of the heart electrical activity associated with different cardiac rhythms. In this study we propose a non(More)
Cardiac morbidity and mortality increases with the population age. To investigate the underlying pathological mechanisms, and suggest new ways to reduce clinical risks, computational approaches complementing experimental and clinical investigations are becoming more and more important. Here we explore the possible processes leading to the occasional onset(More)
We computed 3 linear and 20 nonlinear HRV indexes on 24-h Holter recordings from 200 stable CHF patients (age 52+9 yrs, NYHA II-III, LVEF 24+6%) with the aim to assess i) the mutual interrelationships between these indexes and ii) their prognostic value towards cardiac death. We found high correlations between variables, with potential bias in fitting(More)
Ventricular tachyarrhythmia (VT) onset is studied by reviewing spontaneous intracardiac electrograms (EGMs) from coronary artery disease (CAD) and dilated cardiomyopathies (DCM) patients with implantable cardioverter-defibrillators (ICD). A total of 165 VT episodes (79 CAD and 86 DCM) from 37 patients (26 CAD and 11 DCM) are analysed. Modes of VT onset are(More)
In previous studies investigating intracardiac electrograms (Egm) obtained from implantable cardioverter defibrillators (ICD), the presence of Diastolic Micro-Signals (DMS) preceding the initiation of ventricular tachyarrhythmias (VT) has been observed both in coronary artery disease (CAD) and in dilated cardiomyopathy (DCM). We propose a mechanism, based(More)
Mechanisms involved in the initiation of fibrillation and defibrillation are complex and still not totally understood. This paper computationally investigated the effect of monophasic, biphasic and reversed biphasic stimuli on single cardiomyocyte, with a modified Ten Tusscher model of human ventricular action potential (AP) and calcium dynamics. Three(More)
Aim: Coronary Artery Disease (CAD) and Dilated Cardiomyopathy (DCM) are structurally different heart diseases. Spontaneous ventricular tachyarrhythmias (VT) from implantable cardio-defibrillators (ICD) are studied to explore clinical differences between CAD and DCM. Methods: The analysis is focused on: number of VT episodes, variability of the VT onset(More)