Aldo Casaleggio

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The new generation of Implantable Cardioverter Defibrillators (ICDs) allows storage of intracardiac electrograms (EGMs) recorded immediately before the onset of malignant ventricular tachyarrhythmias (VTs) and during their course. Although all devices base most of diagnostic parameters on the bipolar EGMs, some of them allow two types of EGM recordings:(More)
Heart rate variability signals obtained from 24 h recordings are analyzed for normal and pathological subjects. This time series contains information about the autonomic nervous system action regulating the beat-to-beat heart rate. Nonlinear contributions to the long period variability have been assessed by the calculation of the entire spectrum of Lyapunov(More)
Implantable cardioverter defibrillators (ICDs) can store intracardiac electrograms (EGMs) in sinus rhythm (SR), at the onset of spontaneous ventricular tachyarrhythmias (VT) or during their course. This allows the investigation of unknown features of the heart electrical activity associated with different cardiac rhythms. In this study we propose a non(More)
Cardiac morbidity and mortality increases with the population age. To investigate the underlying pathological mechanisms, and suggest new ways to reduce clinical risks, computational approaches complementing experimental and clinical investigations are becoming more and more important. Here we explore the possible processes leading to the occasional onset(More)
We computed 3 linear and 20 nonlinear HRV indexes on 24-h Holter recordings from 200 stable CHF patients (age 52+9 yrs, NYHA II-III, LVEF 24+6%) with the aim to assess i) the mutual interrelationships between these indexes and ii) their prognostic value towards cardiac death. We found high correlations between variables, with potential bias in fitting(More)
Ventricular tachyarrhythmia (VT) onset is studied by reviewing spontaneous intracardiac electrograms (EGMs) from coronary artery disease (CAD) and dilated cardiomyopathies (DCM) patients with implantable cardioverter-defibrillators (ICD). A total of 165 VT episodes (79 CAD and 86 DCM) from 37 patients (26 CAD and 11 DCM) are analysed. Modes of VT onset are(More)
The high frequency dielectric constant of poly-adenine (poly-A) was measured between 1 MHz and 1 GHz. The purpose of these experiments was to investigate the state of water molecules that are bound to the charged groups of the poly-A molecule. Analysis of the data using the Maxwell's mixture equation revealed the dielectric constant of bound water higher(More)
Aim of this paper is to propose a new parameter, based on 24-hour holter recording, that quantifies abnormal ventricular activity by calculating the peak ectopic rate (PEAK_ER) of every patient. This parameter is tested on a population of 200 heart failure (HF) patients in sinus rhythm (age (median [interquartile range]): 54 years [47-58], ejection fraction(More)
Aim: This study investigates circadian distribution of ventricular tachyarrhythmias (VT) in coronary artery disease (CAD) and dilated cardiomyopathy (DCM) patients that received an implantable cardioverter defibrillator (ICD) as secondary prevention. Methods: 37 patients are studied. Times of VT episode are retrieved from data log of the ICD; the analysis(More)