Aldo Casaleggio

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The new generation of Implantable Cardioverter Defibrillators (ICDs) allows storage of intracardiac electrograms (EGMs) recorded immediately before the onset of malignant ventricular tachyarrhythmias (VTs) and during their course. Although all devices base most of diagnostic parameters on the bipolar EGMs, some of them allow two types of EGM recordings:(More)
Implantable cardioverter defibrillators (ICDs) can store intracardiac electrograms (EGMs) in sinus rhythm (SR), at the onset of spontaneous ventricular tachyarrhythmias (VT) or during their course. This allows the investigation of unknown features of the heart electrical activity associated with different cardiac rhythms. In this study we propose a non(More)
Cardiac morbidity and mortality increases with the population age. To investigate the underlying pathological mechanisms, and suggest new ways to reduce clinical risks, computational approaches complementing experimental and clinical investigations are becoming more and more important. Here we explore the possible processes leading to the occasional onset(More)
AIMS In patients with heart failure (HF), the association between sudden death and arrhythmic pattern at 24-h Holter monitoring [number of ventricular premature contractions per hour (VPCs/h) and presence of non-sustained ventricular tachycardia (NSVT)] has previously been investigated with conflicting results. Since both VPCs/h and NSVT disregard the time(More)
Ventricular tachyarrhythmia (VT) onset is studied by reviewing spontaneous intracardiac electrograms (EGMs) from coronary artery disease (CAD) and dilated cardiomyopathies (DCM) patients with implantable cardioverter-defibrillators (ICD). A total of 165 VT episodes (79 CAD and 86 DCM) from 37 patients (26 CAD and 11 DCM) are analysed. Modes of VT onset are(More)
AIM This paper reports studies of mathematical algorithms for intra-cardiac atrial bipolar electrogram compression suitable with implementation on implantable devices. PATIENTS AND METHODS Bipolar intra-cardiac electrograms (IEGMs) of high right atrium were obtained from 20 patients who underwent electrophysiological studies for arrhythmias. Four thousand(More)
The high frequency dielectric constant of poly-adenine (poly-A) was measured between 1 MHz and 1 GHz. The purpose of these experiments was to investigate the state of water molecules that are bound to the charged groups of the poly-A molecule. Analysis of the data using the Maxwell's mixture equation revealed the dielectric constant of bound water higher(More)
Aim of this paper is to propose a new parameter, based on 24-hour holter recording, that quantifies abnormal ventricular activity by calculating the peak ectopic rate (PEAK_ER) of every patient. This parameter is tested on a population of 200 heart failure (HF) patients in sinus rhythm (age (median [interquartile range]): 54 years [47-58], ejection fraction(More)
Aim: This study investigates circadian distribution of ventricular tachyarrhythmias (VT) in coronary artery disease (CAD) and dilated cardiomyopathy (DCM) patients that received an implantable cardioverter defibrillator (ICD) as secondary prevention. Methods: 37 patients are studied. Times of VT episode are retrieved from data log of the ICD; the analysis(More)