Aldo Casaleggio

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Implantable cardioverter defibrillators (ICDs) can store intracardiac electrograms (EGMs) in sinus rhythm (SR), at the onset of spontaneous ventricular tachyarrhythmias (VT) or during their course. This allows the investigation of unknown features of the heart electrical activity associated with different cardiac rhythms. In this study we propose a non(More)
The new generation of Implantable Cardioverter Defibrillators (ICDs) allows storage of intracardiac electrograms (EGMs) recorded immediately before the onset of malignant ventricular tachyarrhythmias (VTs) and during their course. Although all devices base most of diagnostic parameters on the bipolar EGMs, some of them allow two types of EGM recordings:(More)
AIMS In patients with heart failure (HF), the association between sudden death and arrhythmic pattern at 24-h Holter monitoring [number of ventricular premature contractions per hour (VPCs/h) and presence of non-sustained ventricular tachycardia (NSVT)] has previously been investigated with conflicting results. Since both VPCs/h and NSVT disregard the time(More)
Cardiac morbidity and mortality increases with the population age. To investigate the underlying pathological mechanisms, and suggest new ways to reduce clinical risks, computational approaches complementing experimental and clinical investigations are becoming more and more important. Here we explore the possible processes leading to the occasional onset(More)
BACKGROUND Automatic atrial tachyarrhythmia recognition is crucial in order to allow a correct switching-mode function of dual-chamber pacemakers and to avoid inappropriate shocks of ventricular implantable cardioverter-defibrillators. In this paper we considered three algorithms suitable for implantable devices. The first was based on the atrial cycle(More)
AIM This paper reports studies of mathematical algorithms for intra-cardiac atrial bipolar electrogram compression suitable with implementation on implantable devices. PATIENTS AND METHODS Bipolar intra-cardiac electrograms (IEGMs) of high right atrium were obtained from 20 patients who underwent electrophysiological studies for arrhythmias. Four thousand(More)
Aim: This work investigates the correlation between the cardiac electrical activity underlying spontaneous ventricular tachyarrhythmias and their modes of onset. Signals: We analyzed 81 episodes of spontaneous ventricular tachycardia (VT) and ventricular fibrillation (VF) lasting at least 5 seconds from 17 patients. The cardiologist classified VT/VF(More)
Mechanisms involved in the initiation of fibrillation and defibrillation are complex and still not totally understood. This paper computationally investigated the effect of monophasic, biphasic and reversed biphasic stimuli on single cardiomyocyte, with a modified Ten Tusscher model of human ventricular action potential (AP) and calcium dynamics. Three(More)