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A T cell-dependent experimental liver injury in mice inducible by concanavalin A.

• Gisa Tiegs, Joachim Hentschel, Albrecht Wendel
• The Journal of clinical investigation
• 1992

Male NMRI or BALB/c mice developed severe liver injury as assessed by transaminase release within 8 h when an intravenous dose greater than 1.5 mg/kg concanavalin A (Con A) was given.… (More)

Glutathione peroxidase.

• Albrecht Wendel
• Methods in enzymology
• 1981

Tumor necrosis factor-induced hepatocyte apoptosis precedes liver failure in experimental murine shock models.

• Marcel Leist, Florian Gantner, I Bohlinger, Gisa Tiegs, P G Germann, Albrecht Wendel
• The American journal of pathology
• 1995

We investigated the role of hepatocyte apoptosis in four different murine models of acute inflammatory liver failure. Liver damage induced in D-galactosamine-sensitized mice by endotoxin infection… (More)

In vivo evidence for a functional role of both tumor necrosis factor (TNF) receptors and transmembrane TNF in experimental hepatitis.

• Susanne Küsters, Gisa Tiegs, +8 authors Matthias Grell
• European journal of immunology
• 1997

The significance of tumor necrosis factor receptor 1 (TNFR1) for TNF function in vivo is well documented, whereas the role of TNFR2 so far remains obscure. In a model of concanavalin A (Con… (More)

Murine hepatocyte apoptosis induced in vitro and in vivo by TNF-alpha requires transcriptional arrest.

• Marcel Leist, Florian Gantner, I Bohlinger, P G Germann, Gisa Tiegs, Albrecht Wendel
• Journal of immunology
• 1994

Freshly isolated mouse hepatocytes were essentially insensitive to TNF-alpha cytotoxicity. However, TNF-alpha induced a concentration-dependent cell death in hepatocytes that had been pretreated with… (More)

International validation of novel pyrogen tests based on human monocytoid cells.

• Sebastian Hoffmann, Anja Peterbauer, +25 authors Thomas Hartung
• Journal of immunological methods
• 2005

It is a requirement that parenteral medicines be tested for pyrogens (fever causing agents) using one of two animal-based tests: the rabbit pyrogen test and the bacterial endotoxin test.… (More)

Hyperventilation induces release of cytokines from perfused mouse lung.

• Alexander von Bethmann, Frank E. Brasch, +5 authors Stefan Uhlig
• American journal of respiratory and critical care…
• 1998

Artificial mechanical ventilation represents a major cause of iatrogenic lung damage in intensive care. It is largely unknown which mediators, if any, contribute to the onset of such complications.… (More)

Metabolic Depletion of Atp by Fructose Inversely Controls Cd95- and Tumor Necrosis Factor Receptor 1–Mediated Hepatic Apoptosis

• Markus Latta, Gerald Künstle, Marcel Leist, Albrecht Wendel
• The Journal of experimental medicine
• 2000

Hepatocyte apoptosis is crucial in several forms of liver disease. Here, we examined in different models of murine liver injury whether and how metabolically induced alterations of hepatocyte ATP… (More)

The lectin-like domain of tumor necrosis factor improves lung function after rat lung transplantation--potential role for a reduction in reactive oxygen species generation.

• Juerg Hamacher, Uz Stammberger, +11 authors Rudolf Lucas
• Critical care medicine
• 2010

OBJECTIVE To test the hypothesis that the lectin-like domain of tumor necrosis factor, mimicked by the TIP peptide, can improve lung function after unilateral orthotopic lung isotransplantation.… (More)

The refined structure of the selenoenzyme glutathione peroxidase at 0.2-nm resolution.

• O. Epp, Rudolf Ladenstein, Albrecht Wendel
• European journal of biochemistry
• 1983

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