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  • Wensi Song, Fan Wang, +4 authors Laura Segatori
  • Biology, Medicine
  • Human molecular genetics
  • 2013 (First Publication: 15 May 2013)
  • Loss-of-function diseases are often caused by destabilizing mutations that lead to protein misfolding and degradation. Modulating the innate protein homeostasis (proteostasis) capacity may lead toContinue Reading
  • Rituraj Pal, Lakshya Bajaj, +7 authors George G. Rodney
  • Medicine, Biology
  • Scientific reports
  • 2016 (First Publication: 1 September 2016)
  • Oxidative stress and aberrant accumulation of misfolded proteins in the cytosol are key pathological features associated with Parkinson's disease (PD). NADPH oxidase (Nox2) is upregulated in theContinue Reading