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- Karin Schwibbert, Alberto Marín-Sanguino, +9 authors Hans Jörg Kunte
- Environmental microbiology
- 2011

The halophilic γ-proteobacterium Halomonas elongata DSM 2581(T) thrives at high salinity by synthesizing and accumulating the compatible solute ectoine. Ectoine levels are highly regulated according to external salt levels but the overall picture of its metabolism and control is not well understood. Apart from its critical role in cell adaptation to… (More)

- Alberto Marín-Sanguino, Néstor V. Torres
- Biotechnology progress
- 2000

In the present work we have applied the indirect optimization method (Torres, N. V. et al. Biotechnol. Bioeng. 1996, 49, 247-258) to the maximization of tryptophan biosynthesis in Escherichia coli. The optimization procedure is applied to an updated model of this biochemical system (Xiu, Z-L et al., J. Biotechnol. 1997, 58, 125-140) and thus extended to a… (More)

- Alberto Marín-Sanguino, Néstor V. Torres
- Mathematical biosciences
- 2003

A new method is proposed for the optimization of biochemical systems. The method, based on the separation of the stoichiometric and kinetic aspects of the system, follows the general approach used in the previously presented indirect optimization method (IOM) developed within biochemical systems theory. It is called GMA-IOM because it makes use of the… (More)

- Alberto Marín-Sanguino, Eberhard O. Voit, Carlos González-Alcón, Néstor V. Torres
- Theoretical Biology and Medical Modelling
- 2007

In the past, tasks of model based yield optimization in metabolic engineering were either approached with stoichiometric models or with structured nonlinear models such as S-systems or linear-logarithmic representations. These models stand out among most others, because they allow the optimization task to be converted into a linear program, for which… (More)

- Julio Vera, Carlos González-Alcón, Alberto Marín-Sanguino, Néstor V. Torres
- Computers & OR
- 2010

Available online 10 March 2009

- Carlos Pozo, Alberto Marín-Sanguino, Rui Alves, Gonzalo Guillén-Gosálbez, Laureano Jiménez, Albert Sorribas
- BMC Systems Biology
- 2011

Design of newly engineered microbial strains for biotechnological purposes would greatly benefit from the development of realistic mathematical models for the processes to be optimized. Such models can then be analyzed and, with the development and application of appropriate optimization techniques, one could identify the modifications that need to be made… (More)

- Alberto Marín-Sanguino, Shailendra K. Gupta, Eberhard O. Voit, Julio Vera
- Methods in enzymology
- 2011

In the near future, computational tools and methods based on the mathematical modeling of biomedically relevant networks and pathways will be necessary for the design of therapeutic strategies that fight complex multifactorial diseases. Beyond the use of pharmacokinetic and pharmacodynamic approaches, we propose here the use of dynamic modeling as a tool… (More)

- Christiana Sehr, Andreas Kremling, Alberto Marín-Sanguino
- Metabolites
- 2015

During the last 10 years, systems biology has matured from a fuzzy concept combining omics, mathematical modeling and computers into a scientific field on its own right. In spite of its incredible potential, the multilevel complexity of its objects of study makes it very difficult to establish a reliable connection between data and models. The great number… (More)

- Alberto Marín-Sanguino, Néstor V. Torres, Eduardo Mendoza, Dieter Oesterhelt
- Mathematical biosciences
- 2009

Metabolic Engineering aims to improve the performance of biotechnological processes through rational manipulation rather than random mutagenesis of the organisms involved. Such a strategy can only succeed when a mathematical model of the target process is available. Simplifying assumptions are often needed to cope with the complexity of such models in an… (More)

- Hannes Löwe, Andreas Kremling, Alberto Marín-Sanguino
- Front. Genet.
- 2016

The time-scale hierarchies of a very general class of models in differential equations is analyzed. Classical methods for model reduction and time-scale analysis have been adapted to this formalism and a complementary method is proposed. A unified theoretical treatment shows how the structure of the system can be much better understood by inspection of two… (More)