Alberto La Rosa

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BACKGROUND Antiretroviral regimens with simplified dosing and better safety are needed to maximize the efficiency of antiretroviral delivery in resource-limited settings. We investigated the efficacy and safety of antiretroviral regimens with once-daily compared to twice-daily dosing in diverse areas of the world. METHODS AND FINDINGS 1,571 HIV-1-infected(More)
Reconfigurable processors, in which part of the instruction set can be defined dynamically at run time, hold the promise to cover a broad span of applications with low cost and good performance. They are a possible solution to the silicon provider’s dilemma between specialization, resulting in fewer parts per design and thus higher costs, and(More)
This paper introduces an architectural simulation environment, aimed at defining the best SOC architecture for complex system-level applications. The application is modeled using an abstract Timing Modeling Language, that describes the requests (e.g., memory accesses, I/Os, etc.) that the application makes to the architecture. The abstract architecture is(More)
A 58-year-old man was referred to us because of anal bleeding. Digital rectal examination revealed a 1.2 x 0.8 cm-sessile villous tumor located in the anal canal and lower rectum. Pruritus was lacking and there were no erythematous lesions or any skin lesion in the perianal region. Histologic examination of the excised lesion revealed the presence of an(More)
This paper describes an approach to hardware/software design space exploration for reconfigurable processors. The existing compiler tool-chain, because of the user-definable instructions, needs to be extended in order to offer developers an easy way to explore design space. Such extension often is not easy to use for developer that have only a software(More)
Little is known about how the prevalence and incidence of neurological disease in HIV-infected patients in resource-limited settings. We present an analysis of neurological and neurocognitive function in antiretroviral naïve individuals in multinational resource-limited settings. This prospective multinational cohort study, a substudy of a large(More)
Modern embedded systems must execute a variety of high performance real-time tasks, such as audio and image compression and decompression, channel coding and encoding, etc. Reconfigurable platforms can effectively be used in these cases, because they allow to re-use the architecture for as many applications as possible.This paper describes the(More)
BACKGROUND Anemia is a known risk factor for clinical failure following antiretroviral therapy (ART). Notably, anemia and inflammation are interrelated, and recent studies have associated elevated C-reactive protein (CRP), an inflammation marker, with adverse human immunodeficiency virus (HIV) treatment outcomes, yet their joint effect is not known. The(More)