Proteolytic processing of lysyl oxidase–like-2 in the extracellular matrix is required for crosslinking of basement membrane collagen IV
- Alberto J. López-Jiménez, T. Basak, R. Vanacore
- BiologyJournal of Biological Chemistry
- 1 September 2017
This study demonstrates that LOXL2 is processed extracellularly by serine proteases, generating a 65-kDa form lacking the first two scavenger receptor cysteine-rich domains, and demonstrates that proteolytic processing is an important event that allows LO XL2-mediated crosslinking of basement membrane collagen IV.
Chitosan nanoparticles loaded with garlic essential oil: A new alternative to tebuconazole as seed dressing agent
- María Mondéjar-López, Á. Rubio-Moraga, Enrique Niza
- BiologyCarbohydrate Polymers
The application of ozonated water rearranges the Vitis vinifera L. leaf and berry transcriptomes eliciting defence and antioxidant responses
- A. Campayo, S. Savoi, G. L. Alonso
- MedicineScientific Reports
- 14 April 2021
The response to ozone was observed to be organ and developmental stage-dependent, with a decrease of the number of DEGs in the fruit from the onset of ripening to later stages, and genes related to cell wall development and secondary metabolites were generally down-regulated after ozone treatment.
Lysyl Oxidase-like-2 Cross-links Collagen IV of Glomerular Basement Membrane*
- Carolina Añazco, Alberto J. López-Jiménez, R. Vanacore
- BiologyJournal of Biological Chemistry
- 21 October 2016
It is demonstrated that LOXL2 is a novel component of the molecular machinery that forms cross-linked collagen IV networks, which are essential for glomerular basement membrane stability and molecular ultrafiltration function.
Loss of function of Colgalt1 disrupts collagen post-translational modification and causes musculoskeletal defects
- Krista A. Geister, Alberto J. López-Jiménez, Scott Houghtaling, Tzu-Hua Ho, R. Vanacore, D. Beier
- BiologyDisease Models & Mechanisms
- 1 June 2019
A novel mouse mutant is characterized that has a defect in collagen glycosylation, which appears to affect muscle development, and it is hypothesized that the Colgalt1 mutant could serve as a model of a human connective tissue disorder and/or congenital muscular dystrophy or myopathy.
De Novo Polymerase Activity and Oligomerization of Hepatitis C Virus RNA-Dependent RNA-Polymerases from Genotypes 1 to 5
- P. Clemente-Casares, Alberto J. López-Jiménez, A. Mas
- BiologyPLoS ONE
- 7 April 2011
Results presented in this study reveal the existence of genotypic differences in NS5B de novo activity and oligomerization, and allow us to define two regions, one consisting of residues Glu128, Asp129, and Glu248, and the other consisting of residue of αT helix possibly involved in NS 5B-NS5B interactions.
A New Glycosyltransferase Enzyme from Family 91, UGT91P3, Is Responsible for the Final Glucosylation Step of Crocins in Saffron (Crocus sativus L.)
- Alberto J. López-Jiménez, Sarah Frusciante, L. Gómez-Gómez
- BiologyInternational Journal of Molecular Sciences
- 1 August 2021
Results suggest a role of UGT91P3 in the biosynthesis of highly glucosylated crocins in saffron, and that it represents the last missing gene in crocin biosynthesis.
Identification and characterization of apocarotenoid modifiers and carotenogenic enzymes for biosynthesis of crocins in Buddleja davidii flowers.
- G. Diretto, Alberto J. López-Jiménez, L. Gómez-Gómez
- BiologyJournal of Experimental Botany
- 2 April 2021
Comparative correlation network analysis is used to study how the synthesis of these valuable apocarotenoids diverges among B. davidii, Gardenia jasminoides, and Crocus sativus, highlighting distinctive differences which could be the basis of the differential accumulation of crocins in the three species.
Comparative evaluation of carvacrol and eugenol chitosan nanoparticles as eco-friendly preservative agents in cosmetics.
- María Mondéjar-López, Alberto J. López-Jiménez, Joaquin C. García Martínez, O. Ahrazem, L. Gómez-Gómez, Enrique Niza
- MedicineInternational Journal of Biological…
- 28 February 2022
Fortification and bioaccessibility of saffron apocarotenoids in potato tubers
- Lourdes Gómez Gómez, Lucía Morote, O. Ahrazem
- MedicineFrontiers in Nutrition
- 30 November 2022
Carotenoids are C40 isoprenoids with well-established roles in photosynthesis, pollination, photoprotection, and hormone biosynthesis. The enzymatic or ROS-induced cleavage of carotenoids generates a…