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- A Imparato, L Peliti
- 2006

We obtain a simple direct derivation of the differential equation governing the entropy flow probability distribution function of a stochastic system first obtained by Lebowitz and Spohn. We show that the solution of this equation satisfies the well known fluctuation relations for the entropy also for finite times. A trajectory sampling algorithm allowing… (More)

- M Caraglio, A Imparato, A Pelizzola
- Physical review. E, Statistical, nonlinear, and…
- 2011

An Ising-like model of proteins is used to investigate the mechanical unfolding of the green fluorescent protein along different directions. When the protein is pulled from its ends, we recover the major and minor unfolding pathways observed in experiments. Upon varying the pulling direction, we find the correct order of magnitude and ranking of the… (More)

- Alberto Imparato
- The Journal of chemical physics
- 2006

We study the elastic response of bilayer membranes with fixed projected area to both the stretching and shape deformations. A surface tension is associated to each of these deformations. By using model amphiphilic membranes and computer simulations, we are able to observe both the types of deformation, and thus, both the surface tensions, related to each… (More)

- A Imparato, A Pelizzola
- Physical review letters
- 2008

Mechanical unfolding and refolding of ubiquitin are studied by Monte Carlo simulations of a Gō model with binary variables. The exponential dependence of the time constants on the force is verified, and folding and unfolding lengths are computed, with good agreement with experimental results. Furthermore, the model exhibits intermediate kinetic states, as… (More)

- Simon Mitternacht, Stefano Luccioli, Alessandro Torcini, Alberto Imparato, Anders Irbäck
- Biophysical journal
- 2009

We investigate the mechanical unfolding of the tenth type III domain from fibronectin (FnIII(10)) both at constant force and at constant pulling velocity, by all-atom Monte Carlo simulations. We observe both apparent two-state unfolding and several unfolding pathways involving one of three major, mutually exclusive intermediate states. All three major… (More)

- Kaare Mikkelsen, Alberto Imparato, Alessandro Torcini
- Physical review letters
- 2013

The collective dynamics of excitatory pulse coupled neurons with spike-timing dependent plasticity is studied. The introduction of spike-timing dependent plasticity induces persistent irregular oscillations between strongly and weakly synchronized states, reminiscent of brain activity during slow-wave sleep. We explain the oscillations by a mechanism, the… (More)

- Pétur O Heidarsson, Mariela R Otazo, +7 authors Ciro Cecconi
- Structure
- 2013

EF-hand calcium sensors respond structurally to changes in intracellular Ca(2+) concentration, triggering diverse cellular responses and resulting in broad interactomes. Despite impressive advances in decoding their structure-function relationships, the folding mechanism of neuronal calcium sensors is still elusive. We used single-molecule optical tweezers… (More)

- Alberto Imparato, Stefano Luccioli, Alessandro Torcini
- Physical review letters
- 2007

The equilibrium free-energy landscape of an off-lattice model protein as a function of an internal (reaction) coordinate is reconstructed from out-of-equilibrium mechanical unfolding manipulations. This task is accomplished via two independent methods: by employing an extended version of the Jarzynski equality (EJE) and the protein inherent structures… (More)

- A Imparato, L Peliti
- Physical review. E, Statistical, nonlinear, and…
- 2006

We consider a driven Brownian particle, subject to both conservative and nonconservative applied forces, whose probability evolves according to the Kramers equation. We derive a general fluctuation relation, expressing the ratio of the probability of a given Brownian path in phase space with that of the time-reversed path, in terms of the entropy flux to… (More)

- A Imparato, A Pelizzola, M Zamparo
- Physical review letters
- 2007

The mechanical unfolding of proteins is studied by extending the Wako-Saitô-Muñoz-Eaton model. This model is generalized by including an external force, and its thermodynamics turns out to be exactly solvable. We consider two molecules, the 27th immunoglobulin domain of titin and protein PIN1. We determine equilibrium force-extension curves for the titin… (More)