Alberto Gasparoni

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BACKGROUND Beta-catenin, an E-cadherin-associated protein involved in cell-cell adhesion and signaling, has been hypothesized to translocate to the nucleus and activate transcription in several human cancers, including oral squamous cell carcinomas (OSCC). METHODS In the present study, we analyzed the subcellular localization of beta-catenin in cultures(More)
This study examines differences between cultures of normal human oral epithelial cells and two squamous cell carcinoma cell lines (SCC15 and SCC25) in the expression of structural proteins, adhesion molecules, plasma membrane lipid composition, and intercellular junctions. Based on immunocytochemistry, most normal cell cultures appeared to express more(More)
Dental amalgam fillings are known to release significant amounts of mercury (Hg) in saliva which could represent a continuous source of oxidative damage to mouth tissues. The present investigation was aimed at verifying this hypothesis by determining a possible correlation between salivary Hg levels and salivary total antioxidant activity (TAA), which is(More)
Dental amalgam (AMG) is the most diffused dental filling material. Since it is constituted for at least 40-45% of Hg, many questions have raised about its safe use. Hg particles from dental amalgam dissolve in saliva and, being ingested, they reach the blood stream through the intestinal mucosa. It has been demonstrated that amalgam fillings continuously(More)
OBJECTIVE To evaluate beta-catenin expression in human tooth germ development. STUDY DESIGN Specimens of 7 human fetuses aged between the ninth and sixteenth week were examined for beta-catenin expression by immunohistochemistry. RESULTS In the bud stage, we observed catenin membranous positivity for all primitive dental lamina and dental ridge cells,(More)
The major goal of endodontic therapy has been achieved by condensing filling materials into the root canal. It is not uncommon to find excess material in the periapical tissue. It therefore becomes obligatory to use filling materials that have acceptable biocompatibility. The purpose of this investigation was to obtain a "toxicity profile" of some root(More)
The results of our recent microscopy studies clearly have demonstrated the constant presence of numerous metachromatic cells in healthy human gingival connective tissue. Despite the great number of studies on mast cell population in many human organs (lung, skin, uterus, and bowel), at the present time few are the studies regarding the morphostructural(More)
Quantitative and qualitative control of oral bacterial flora is a major issue in oral pathology and in the prophylaxis against cavities. Recent findings suggest that it is possible to induce local immune responses delivering antigens on palatine tonsils. M cells play an important role in the start of the immune response. These cells are located in the(More)