Alberto Garay

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The effects of increasing calcium concentration and isoproterenol on myocardial relaxation were compared in cat and rat papillary muscles and toad ventricular strips. Isoproterenol effects were studied at equivalent positions of the calcium contractility response curve in the three species: at the plateau and at 25% and 50% of maximum. Calcium concentration(More)
We report a 42-year-old man who, for 8 months, had intermittent motor abnormalities and mild difficulty falling asleep. A diagnosis of fatal familial insomnia (FFI) became evident over the next 6 months when he developed progressive insomnia, myoclonus, sympathetic hyperactivity, and dementia. The amyloid or prion protein (PrP) genotype showed features(More)
The type of antagonism between verapamil, nifedipine or prenylamine and calcium or isoproterenol on myocardial contractility, was investigated in cat papillary muscles. Dose response curves to calcium or to isoproterenol were performed in the absence and presence of a single dose of either verapamil, nifedipine or prenylamine. Non significantly different(More)
BACKGROUND Prognostic impact of anaemia in the elderly with acute coronary syndromes has not been specifically analysed, and little information exists about causes of mortality in this setting. METHODS We prospectively included consecutive patients with acute coronary syndromes. Anaemia was defined as haemoglobin < 130 g/L in men, and < 120 g/L in women.(More)
BACKGROUND Bleeding events after an acute coronary syndrome have a negative impact on prognosis. Available risk scores are limited by suboptimal accuracy, prediction of only in-hospital events and absence of patients treated with new antiplatelet agents in the current era of widespread use of percutaneous coronary intervention. DESIGN The BleeMACS(More)
BACKGROUND The prevalence and outcome of patients with cancer that experience acute coronary syndrome (ACS) have to be determined. METHODS AND RESULTS The BleeMACS project is a multicentre observational registry enrolling patients with acute coronary syndrome undergoing percutaneous coronary intervention worldwide in 15 hospitals. The primary endpoint was(More)
INTRODUCTION AND OBJECTIVE Anemia is a common comorbidity in patients with acute coronary syndromes (ACS), and is associated with higher risk for both bleeding and ischemic complications. We aimed to assess the predictive ability of bleeding risk scores (Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early(More)
The present experiments were designed to analyze the effect of verapamil, nifedipine and isoproterenol on myocardial contractility (+dT/dtmax) and time to peak tension (TTP) and its dependence on extracellular calcium concentration (Ca2+). The experiments were performed on cat papillary muscles from reserpinized cats. At (Ca2+) 1.34 mM the negative(More)
OBJECTIVE Analysis of the consequence of the preoperative information delivered orally to patients requiring surgery for benign pathology of the thyroid gland from various perspective (head and neck surgeon, physician, judge, lawyer). METHODS Prospective study conducted in an academic tertiary care referral center. Inception cohort of 123 patients with(More)