Alberto Delgado

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T cells infiltrating tumors have a decreased expression of signal transduction proteins, a diminished ability to proliferate, and a decreased production of cytokines. The mechanisms causing these changes have remained unclear. We demonstrated recently that peritoneal macrophages stimulated with interleukin 4 + interleukin 13 produce arginase I, which(More)
Although Constraint Programming (CP) is considered a useful tool for tackling combinatorial problems, its lack of flexibility when dealing with uncertainties and preferences is still a matter of research. Several formal frameworks for soft constraints have been proposed within the CP community: all of them seem to be theoretically solid, but few practical(More)
The development of gastritis during Helicobacter pylori infection is dependent on an activated adaptive immune response orchestrated by T helper (Th) cells. However, the relative contributions of the Th1 and Th17 subsets to gastritis and control of infection are still under investigation. To investigate the role of interleukin-21 (IL-21) in the gastric(More)
Helicobacter pylori incites a futile inflammatory response, which is the key feature of its immunopathogenesis. This leads to the ability of this bacterial pathogen to survive in the stomach and cause peptic ulcers and gastric cancer. Myeloid cells recruited to the gastric mucosa during H. pylori infection have been directly implicated in the modulation of(More)
Millions of containers are stowed every week with goods worth billions of dollars, but container vessel stowage is an all but neglected combinatorial optimization problem. In this paper, we introduce a model for stowing containers in a vessel bay which is the result of probably the longest collaboration to date with a liner shipping company on automated(More)
Container vessel stowage planning is a hard combinatorial optimization problem with both high economic and environmental impact. We have developed an approach that often is able to generate near-optimal plans for large container vessels within a few minutes. It decomposes the problem into a master planning phase that distributes the containers to bay(More)
Transition metals are necessary for all forms of life including microorganisms, evidenced by the fact that 30% of all proteins are predicted to interact with a metal cofactor. Through a process termed nutritional immunity, the host actively sequesters essential nutrient metals away from invading pathogenic bacteria. Neutrophils participate in this process(More)
Here we introduce DePathos, a graphical tool for a time-tabling constraint engine (Pathos). Since the core of Pathos is text-based and provides little user-interaction, finding an appropriate solution for large problems (1000-2000 variables) can be a very time consuming process requiring the constant supervision of a constraint programming expert. DePathos(More)