Alberto Delgado

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Although Constraint Programming (CP) is considered a useful tool for tackling combinatorial problems, its lack of flexibility when dealing with uncertainties and preferences is still a matter of research. Several formal frameworks for soft constraints have been proposed within the CP community: all of them seem to be theoretically solid, but few practical(More)
The development of gastritis during Helicobacter pylori infection is dependent on an activated adaptive immune response orchestrated by T helper (Th) cells. However, the relative contributions of the Th1 and Th17 subsets to gastritis and control of infection are still under investigation. To investigate the role of interleukin-21 (IL-21) in the gastric(More)
Millions of containers are stowed every week with goods worth billions of dollars, but container vessel stowage is an all but neglected combinatorial optimization problem. In this paper, we introduce a model for stowing containers in a vessel bay which is the result of probably the longest collaboration to date with a liner shipping company on automated(More)
Container vessel stowage planning is a hard combinatorial optimization problem with both high economic and environmental impact. We have developed an approach that often is able to generate near-optimal plans for large container vessels within a few minutes. It decomposes the problem into a master planning phase that distributes the containers to bay(More)
BACKGROUND The objective of this study is to analyze the factors that are associated with the adequacy of empirical antibiotic therapy and its impact in mortality in a large cohort of patients with extended-spectrum β-lactamase (ESBL)--producing Escherichia coli and Klebsiella spp. bacteremia. METHODS Cases of ESBL producing Enterobacteriaceae (ESBL-E)(More)
Transition metals are necessary for all forms of life including microorganisms, evidenced by the fact that 30% of all proteins are predicted to interact with a metal cofactor. Through a process termed nutritional immunity, the host actively sequesters essential nutrient metals away from invading pathogenic bacteria. Neutrophils participate in this process(More)
Here we introduce DePathos, a graphical tool for a time-tabling constraint engine (Pathos). Since the core of Pathos is text-based and provides little user-interaction, finding an appropriate solution for large problems (1000-2000 variables) can be a very time consuming process requiring the constant supervision of a constraint programming expert. DePathos(More)
Inhabitants of Túquerres in the Colombian Andes have a 25-fold higher risk of gastric cancer than inhabitants of the coastal town Tumaco, despite similar H. pylori prevalences. The gastric microbiota was recently shown in animal models to accelerate the development of H. pylori-induced precancerous lesions. 20 individuals from each town, matched for age and(More)