Alberto De Marco

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BACKGROUND Prostaglandin E2 (PGE2), experimentally administered to asthma patients or assayed in murine models, improves allergen-driven airway inflammation. The mechanisms are unknown, but fluctuations of the endogenous cyclooxygenase (COX)-2/prostaglandin/E prostanoid (EP) receptor pathway activity likely contribute to the clinical outcome. We analyzed(More)
Single-stranded oligodeoxynucleotides (ODN), containing nonmethylated cytosine-guanine motifs (CpG ODN), are recognized by the innate immune system as "danger signals." CpG ODN are efficacious immunomodulators but require phosphorothioate (PT) or other backbone modifications for metabolic stability, which cause toxicities in mice and primates. We therefore(More)
BACKGROUND Despite its reported pro-inflammatory activity, cyclooxygenase (COX)-2 has been proposed to play a protective role in asthma. Accordingly, COX-2 might be down-regulated in the airway cells of asthmatics. This, together with results of experiments to assess the impact of COX-2 blockade in ovalbumin (OVA)-sensitized mice in vivo, led us to propose(More)
OBJECTIVE The aim of this study was to find a proper experimental design and to evaluate n-butyl-2-cyanoacrylate (Histoacryl) as a fixation method for a light-weight and large pore PP mesh (Synthetic PP Mesh-1) using the sheep as an animal model. METHODS Posterior vaginal implantation by means of episiotomy was used to implant 8 ewes which were evaluated(More)
An appropriate information and logistics structure is of paramount importance for the local fresh food supply chain, which is characterized by market fragmentation and little coordination among suppliers and customers. Mobile communication technologies can help meet this goal because of their large diffusion and real time information management. In this(More)
Supply chain management supported by digital services is one of the most promising areas of research that have emerged in the last years since it has a tremendous potential to improve both operational and economic performance. In particular, distribution of freight is a field that lends itself to the application of the latest information and communication(More)
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