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BACKGROUND Loss of genomic imprinting (LOI) of the insulin-like growth factor-2 gene (IGF2) is an epigenetic change involving abnormal activation of the normally silent maternally inherited allele. LOI of IGF2 gene is found in tumor tissue, normal adjoining mucosa and peripheral blood lymphocytes (PBL) of some patients with colorectal cancer (CRC),(More)
We propose a simple preconditioning for the equations of motion of constrained mechanical systems in index three form. The scaling transformation is applied to the displacement-velocity-multiplier and to the reduced displacement-multiplier forms. The analysis of the transformed system shows that conditioning and sensitivity to perturbations become(More)
Inhomogeneous essential boundary conditions must be carefully treated in the formulation of Reduced Order Models (ROMs) for non-linear problems. In order to investigate this issue, two methods are analysed: one in which the boundary conditions are imposed in an strong way, and a second one in which a weak imposition of boundary conditions is made. The ideas(More)
In this paper, we present a new numerical method, the Immersed Element-Free Galerkin Method (IEFGM), for the solution of fluid-structure interaction problems. The technique is a variation of the Immersed Finite Element Method developed by (L. Zhang et al., Journal of Fluids and Structures, 23(6):836-857 (2007)) in which the fluid-solid interaction force is(More)
Introduction: Although one third of febrile seizures are complex, a consensus has still not been reached on how to manage them, as is the case with simple febrile seizures. The objective of this study is to estimate the usefulness of complementary examinations and the risk of associated serious intracranial pathology. Patients and methods: A retrospective(More)
This paper introduces a temperature-based model to simulate the steady-state conduction-advection heat transfer problem in a 3D media undergoing mushy phase change. It is a generalization to 3D of the method previously formulated for solving 2D and axisymmetric transient conduction [1] and steady conduction-advection phase-change problems [2]. The analyzed(More)
Introduction: Acute bronchiolitis (AB) is a very common disease, with a high rate of seasonal hospitalization. Its management requires homogeneous clinical interpretations for which there are different approaches depending on the scales, none of which are properly validated today. Objective: To create an AB severity scale (ABSS) and to validate it.(More)