Alberto B. Diez González

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OBJECTIVE The apparent association between varicella zoster virus (VZV) and multiple sclerosis (MS) has been described. In patients with relapse/remission (R/R) MS we have found high loads of VZV DNA in lymphocytes and in cerebrospinal fluid (CSF), as well as abundant viral particles in CSF visualized by electron microscopy at the time of relapse. Both, the(More)
In this work, we describe a procedure to visualize nonlinear process dynamics using a self-organizing map based local model dynam-ical estimator. The proposed method exploits the topology preserving nature of the resulting estimator to extract visualizations (planes) of insightful dynamical features, that allow to explore nonlinear systems whose behavior(More)
Correlation analysis has always been a key technique for understanding data. However, traditional methods are only applicable on the whole data set, providing only global information on correlations. Correlations usually have a local nature and two variables can be directly and inversely correlated at different points in the same data set. This situation(More)
In the framework of SOM methodology for process and system analysis, we suggest a method for identifying regions in the SOM visualization space corresponding to different conditions of a monitored process by means of a fuzzy rule system, as a way of incorporating expert knowledge to this methodology.
PURPOSE To evaluate the ability of the short-duration transient visual evoked potential (SD-tVEP) to discriminate between healthy eyes and eyes with early to advanced glaucomatous visual field loss. METHODS We tested 30 eyes of 30 healthy controls and 45 eyes of 35 glaucoma patients. Normal eyes had 20/30 or better visual acuity and normal 24-2 Swedish(More)
The aim of this study was to evaluate structural and functional improvement following intraocular pressure (IOP) reduction in patients with glaucoma using Spectral Domain Optical Coherence Tomography (SD-OCT), Visual Field (VF) testing, and Visual Evoked Potentials (VEP). A total of 76 eyes from 61 patients underwent SD-OCT, VF and VEP testing. Sixty-two(More)
In this paper a new method based on the self-organizing map (SOM) is proposed to track and identify changes in the dynamic behaviour of a physical process. In a first stage, a SOM is trained on a parameter space composed of the coefficients of local dynamic models estimated around different operating points of the process. On execution, new models estimated(More)
AIM To evaluate the use of short-duration transient visual evoked potentials (VEP) and color reflectivity discretization analysis (CORDA) in glaucomatous eyes, eyes suspected of having glaucoma, and healthy eyes. METHODS The study included 136 eyes from 136 subjects: 49 eyes with glaucoma, 45 glaucoma suspect eyes, and 42 healthy eyes. Subjects underwent(More)
In typical data mining applications we often have large amounts of data at our disposal along with knowledge often available in quite different ways such as rules, cases, analytical models or correlations among variables. Many classical machine learning methods may result inadequate in this scenario because they seldom allow to make use of all the knowledge(More)
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