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Consensus statement on the diagnosis of multiple system atrophy
We report the results of a consensus conference on the diagnosis of multiple system atrophy (MSA). We describe the clinical features of the disease, which include four domains: autonomicExpand
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Phenomenology and classification of dystonia: a consensus update.
This report describes the consensus outcome of an international panel consisting of investigators with years of experience in this field that reviewed the definition and classification of dystonia.Expand
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Bilateral deep brain stimulation in Parkinson's disease: a multicentre study with 4 years follow-up.
Deep brain stimulation (DBS) is associated with significant improvement of motor complications in patients with severe Parkinson's disease after some 6-12 months of treatment. Long-term results in aExpand
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The impact of deep brain stimulation on executive function in Parkinson's disease.
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) or the internal segment of the globus pallidus (GPi) improves Parkinson's disease and increases frontal blood flow. We assessed theExpand
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Localization of a novel locus for autosomal recessive early-onset parkinsonism, PARK6, on human chromosome 1p35-p36.
The cause of Parkinson disease (PD) is still unknown, but genetic factors have recently been implicated in the etiology of the disease. So far, four loci responsible for autosomal dominant PD haveExpand
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Relief by botulinum toxin of voiding dysfunction due to benign prostatic hyperplasia: results of a randomized, placebo-controlled study.
OBJECTIVES To evaluate the therapeutic role of botulinum toxin injection in men with benign prostatic hyperplasia. METHODS Men with benign prostatic hyperplasia were enrolled in a randomized,Expand
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PINK1 mutations are associated with sporadic early‐onset parkinsonism
We have recently reported homozygous mutations in the PINK1 gene in three consanguineous families with early‐onset parkinsonism (EOP) linked to the PARK6 locus. To further evaluate the pathogenicExpand
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Analysis of blink rate patterns in normal subjects.
The present study measured the normal blink rate (BR) variations in relation to behavioral tasks in 150 healthy volunteers (70 males and 80 females; aged 35.9 +/- 17.9 years, range 5-87 years). TheExpand
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Chronic subthalamic nucleus stimulation reduces medication requirements in Parkinson’s disease
Objective: To reduce antiparkinsonian medication in parkinsonian patients with bilateral high frequency subthalamic nucleus (STN) stimulation. Background: Parkinsonian syndromes are characterized byExpand
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The natural history of multiple system atrophy: a prospective European cohort study
Summary Background Multiple system atrophy (MSA) is a fatal and still poorly understood degenerative movement disorder that is characterised by autonomic failure, cerebellar ataxia, and parkinsonismExpand
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