Albert Zlotnik

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Involvement of chemokine receptors in breast cancer metastasis

Anja Mueller, Bernhard Homey, +11 authors Albert Zlotnik
Nature
2001

Breast cancer is characterized by a distinct metastatic pattern involving the regional lymph nodes, bone marrow, lung and liver. Tumour cell migration and metastasis share many similarities with… (More)

Chemokines: a new classification system and their role in immunity.

The biology of chemokines and their receptors.

Daniele Rossi, Albert Zlotnik
Annual review of immunology
2000

During the last five years, the development of bioinformatics and EST databases has been primarily responsible for the identification of many new chemokines and chemokine receptors. The chemokine… (More)

A new class of membrane-bound chemokine with a CX3C motif

J. Fernando Bazan, Kevin B. Bacon, +6 authors Thomas J. Schall
Nature
1997

Chemokines direct the trafficking of white blood cells in immune surveillance, playing a key role in inflammatory and infectious diseases such as AIDS1–5. All chemokines studied so far are secreted… (More)

A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression.

Dale I Godfrey, Jacqueline Kennedy, Tomomi Suda, Albert Zlotnik
Journal of immunology
1993

We have subdivided mouse CD4-CD8-CD3- triple-negative (TN) thymocytes into four subsets based upon expression of CD44 and CD25, including CD44+CD25-, CD44+CD25+, CD44-CD25+ and CD44-CD25-.… (More)

IL-10 inhibits cytokine production by activated macrophages.

David F. Fiorentino, Albert Zlotnik, Tim R. Mosmann, Maureen Howard, Anne O'Garra
Journal of immunology
1991

IL-10 inhibits the ability of macrophage but not B cell APC to stimulate cytokine synthesis by Th1 T cell clones. In this study we have examined the direct effects of IL-10 on both macrophage cell… (More)

Selective Recruitment of Immature and Mature Dendritic Cells by Distinct Chemokines Expressed in Different Anatomic Sites

M C Dieu, Béatrice Vanbervliet, +7 authors Christophe Caux
The Journal of experimental medicine
1998

DCs (dendritic cells) function as sentinels of the immune system. They traffic from the blood to the tissues where, while immature, they capture antigens. They then leave the tissues and move to the… (More)

The chemokine superfamily revisited.

The chemokine superfamily consists of a large number of ligands and receptors. At first glance, this family appears redundant and their ligand-receptor relationships promiscuous, making its study… (More)

The chemokine and chemokine receptor superfamilies and their molecular evolution

Albert Zlotnik, Osamu Yoshie, H. Nomiyama
Genome Biology
2006

The human chemokine superfamily currently includes at least 46 ligands, which bind to 18 functionally signaling G-protein-coupled receptors and two decoy or scavenger receptors. The chemokine ligands… (More)

Chemokines and the arrest of lymphocytes rolling under flow conditions.

James J Campbell, Julie Hedrick, Albert Zlotnik, Michael A. Siani, Darren A Thompson, Eugene C. Butcher
Science
1998

Circulating lymphocytes are recruited from the blood to the tissue by rolling along the endothelium until being stopped by a signaling event linked to the Gialpha subunit of a heterotrimeric… (More)

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