Isolation of a Pregnenolone Metabolite, Δ5-Pregnene-3α,16α,20α-triol, from the Urine of Normal Men
- L. Romanoff, M. Baxter, K. K. Malhotra, Albert W. Thomas
- Chemistry, Medicine
- 1 May 1967
A 3H-labeled 3α-hydroxy-Δ5 steroid was isolated from the pooled glucuronidase-hydrolyzed extracts of urine collected from 6 healthy young men, aged 22–30, 3 of whom had received a tracer dose of pregnenolone-7α-3H (3β-Hydroxy- Δ5-pregnen-20-one) intravenously.
Metabolism of 17α-Hydroxypregnenolone-7α-3H and 17α-Hydroxyprogesterone-4-14C in Young and Elderly Men1
- L. Romanoff, K. K. Malhotra, M. Baxter, Albert W. Thomas, G. Pincus
- 1 June 1968
With the exception that elderly subjects converted a significantly greater percentage of Δ4-17-OHP to P-triol, aging had no effect on age-related radioactivity in young and elderly men.