Albert Pujol

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Network and systems biology offer a novel way of approaching drug discovery by developing models that consider the global physiological environment of protein targets, and the effects of modifying them, without losing the key molecular details. Here we review some recent advances in network and systems biology applied to human health, and discuss how they(More)
A key event in the pathogenesis of Alzheimer's disease (AD) is the accumulation of amyloid-β (Aβ) species in the brain, derived from the sequential cleavage of the amyloid precursor protein (APP) by β- and γ-secretases. Based on a systems biology study to repurpose drugs for AD, we explore the effect of lansoprazole, and other proton-pump inhibitors (PPIs),(More)
INTRODUCTION AND GOALS At present different options co-exist for treating a benign tumour of the parotid gland, which has led to some confusion about the extent of resection performed in each case. In an effort to improve this situation, we created a classification system to define the areas removed. We started using this classification in July, 2006, and(More)
PCA-like methods make use of an estimation of the covariances between sample variables. This estimation does not take into account their topological relationships. This paper proposes how to use these relationships in order to estimate the covariances in a more robust way. The new method Topological Principal Component Analysis (TPCA) is tested using both(More)
BACKGROUND Perceived age has been defined as the age that a person is visually estimated to be on the basis of physical appearance. In a society where a youthful appearance are an object of desire for consumers, and a source of commercial profit for cosmetic companies, this concept has a prominent role. In addition, perceived age is also an indicator of(More)
Hausdorff distance is a deformation tolerant measure between two sets of points. The main advantage of this measure is that it does not need an explicit correspondence between the points of the two sets. This paper presents the application to automatic face recognition of a novel supervised Hausdorff-based measure. This measure is designed to minimize the(More)
BACKGROUND The prevalence of type 2 diabetes is increasing worldwide, accounting for 85-95% of all diagnosed cases of diabetes. Clinical trials provide evidence of benefits of low-carbohydrate ketogenic diets in terms of clinical outcomes on type 2 diabetes patients. However, the molecular events responsible for these improvements still remain unclear in(More)