Albert Pujol

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A key event in the pathogenesis of Alzheimer's disease (AD) is the accumulation of amyloid-β (Aβ) species in the brain, derived from the sequential cleavage of the amyloid precursor protein (APP) by β- and γ-secretases. Based on a systems biology study to repurpose drugs for AD, we explore the effect of lansoprazole, and other proton-pump inhibitors (PPIs),(More)
Hausdorff distance is a deformation tolerant measure between two sets of points. The main advantage of this measure is that it does not need an explicit correspondence between the points of the two sets. This paper presents the application to automatic face recognition of a novel supervised Hausdorff-based measure. This measure is designed to minimize the(More)
PCA-like methods make use of an estimation of the covariances between sample variables. This estimation does not take i n to account their topological relationships. This paper proposes how to use these relationships in order to estimate the covari-ances in a more robust way. The new method Topological Principal Component Analysis (TPCA) is tested using(More)
This paper introduces a supervised discriminant Hausdorff distance that fits into the framework for automatic face analysis and recognition proposed in [1]. Our proposal relies solely on face shape variation contrarily to most of the successful model-based approaches, and results show comparable performance to them. The whole framework is based in a new set(More)
The possible influence of weaning on the development of different neural mechanisms involved in stress-induced antinociception (SIA) was studied. Male Wistar albino rats were used for studies on adult and pre- and postweanling rats of 20 and 25 days of age, respectively. Animals were stressed by warm-water (20C) swimming for 3-min periods. Antinociception(More)
The effects of a daily injection of the opioid antagonist naltrexone (NALTX, 1 mg/kg SC), from birth to weaning day, on several behavioral parameters were investigated in adult rats of both genders. This work uses three behavioral tests. The use of the open-field test in addition to the holeboard and plus-maze tests allows the measurement of complementary(More)