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  • E. Robert McDonald, Antoine de Weck, +97 authors William R. Sellers
  • Biology, Medicine
  • Cell
  • 2017 (First Publication: 27 July 2017)
  • Elucidation of the mutational landscape of human cancer has progressed rapidly and been accompanied by the development of therapeutics targeting mutant oncogenes. However, a comprehensive mapping ofContinue Reading
  • Yohan Lee, Jason Liu, +10 authors Stanley Nelson
  • Medicine, Biology
  • Brain pathology
  • 2009 (First Publication: 20 November 2009)
  • Meningiomas are one of the most common adult brain tumors. For most patients, surgical excision is curative. However, up to 20% recur. Currently, the molecular determinants predicting recurrence andContinue Reading
  • Benjamin M. Ellingson, Timothy F. Cloughesy, +8 authors Albert Lai
  • Psychology, Medicine, Computer Science
  • NeuroImage
  • 2012 (First Publication: 16 January 2012)
  • Promoter methylation of O6-methylguanine DNA methyltransferase (MGMT) is associated with a favorable prognosis in glioblastoma multiforme (GBM) and has been hypothesized to occur early in tumorContinue Reading
  • Wei Chen, Sibylle Delaloye, +8 authors Timothy F. Cloughesy
  • Medicine
  • Journal of clinical oncology : official journal…
  • 2007 (First Publication: 20 October 2007)
  • PURPOSE Evaluation of treatment effects in malignant brain tumors is challenging because of the lack of reliable response predictors of tumor response. This study examines the predictive value ofContinue Reading
  • Whitney B. Pope, Robert M Prins, +18 authors Linda M Liau
  • Biology, Medicine
  • Journal of Neuro-Oncology
  • 2011 (First Publication: 1 March 2012)
  • Mutations of the isocitrate dehydrogenase 1 and 2 genes (IDH1 and IDH2) are commonly found in primary brain cancers. We previously reported that a novel enzymatic activity of these mutations resultsContinue Reading
  • Whitney B. Pope, Xin Joe Qiao, +22 authors Timothy F. Cloughesy
  • Medicine
  • Journal of Neuro-Oncology
  • 2012 (First Publication: 1 July 2012)
  • We have tested the predictive value of apparent diffusion coefficient (ADC) histogram analysis in stratifying progression-free survival (PFS) and overall survival (OS) in bevacizumab-treated patientsContinue Reading
  • Thomas Sandmann, Richard Bourgon, +16 authors Carlos Bais
  • Medicine
  • Journal of clinical oncology : official journal…
  • 2015 (First Publication: 29 June 2015)
  • PURPOSE The AVAglio (Avastin in Glioblastoma) and RTOG-0825 randomized, placebo-controlled phase III trials in newly diagnosed glioblastoma reported prolonged progression-free survival (PFS), but notContinue Reading