Albert Gidari

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Streptozotocin (STZ) increased the activity of mouse hepatic glutathione (GSH) S-transferases assayed with 1-chloro-2,4-dinitrobenzene. Nicotinamide administered prior to STZ prevented the hyperglycemia indicative of STZ-induced diabetes, but had no effect on the increase in GSH S-transferase activity caused by the drug. Another diabetogenic agent, alloxan,(More)
Dexamethasone, a prototypic synthetic glucocorticoid, was added to cultures of human fetal liver and adult marrow cells to assess its effects on erythroid colony and burst formation. Dexamethasone decreased the number of fetal liver erythroid colonies and bursts formed in the presence of erythropoietin, and also decreased the number of cells per colony. The(More)
Pretreatment of pregnant mice (CD-1) with intravenous dexamethasone phosphate (10(-3)-10(-7) g/mouse), a synthetic glucocorticoid, reduced the number of erythroid colonies that formed when 15-day-old fetal liver erythroid progenitor cells (3 X 10(4] were cultured for two days in plasma clots containing exogenous erythropoietin (Epo) (25 mU). The(More)
Pretreatment of pregnant mice with aminoglutethimide phosphate, an inhibitor of glucocorticoid synthesis, increases the content of fetal liver erythroid colony-forming cells (CFU-E), as assessed by the formation of erythroid colonies in vitro by fetal liver cells in plasma clots containing exogenous erythropoietin. In addition, the inability of(More)