Albenaa Todorova

Learn More
This clinical trial was designed to evaluate the efficacy of the external nasal dilator Breathe Right (nasal strip) on snoring. The assessment of snoring intensity and duration as well as the sleep quality without the Breathe Right nasal strip and after application was performed in 30 out-patients with primary habitual snoring. An all-night polysomnographic(More)
Sleep in humans is classically assessed by recording a multichannel electroencephalogram (EEG) in connection with an electrooculogram (EOG) and an electromyogram (EMG). In general, human sleep is manually staged into 6 categories (from awake through REM sleep to stage 4 reflecting deep sleep) on the basis of a visual inspection of EEG periods (epochs) of 20(More)
In this clinical trial the effects on the central nervous system (CNS) of two commercially available extracts of St. John's wort (Texx 300 and Jarsin 300) were compared with those of placebo in a group of healthy young volunteers (n = 35) following a single blind study design. Measurements were carried out on the first day and after repetitive drug(More)
OBJECTIVE The aim of this analysis was to verify objective correlates of the clinical improvement of migraine in patients by means of quantitative topographical EEG (qEEG). METHODS Overall 40 migraine-outpatients participated in this retrospective analysis of prophylactic migraine treatment over 3-8 months with 1600 to 2000 mg cyclandelate daily. In all(More)
Antimuscarinic compounds are increasingly used to treat the symptoms of overactive bladder; however, their use is often restricted by peripheral adverse effects (AEs). On the other hand, data regarding their influence on the central nervous system (CNS) are limited. This randomized, single-blind, parallel-group quantitative-topographical EEG (qEEG) study of(More)
Effects of repeated twice daily i.p. administration of haloperidol (0.5 mg/kg), clozapine (3.0 mg/kg) and prothipendyl (1.0 mg/kg) on spontaneous A9 and A10 cell activity were studied using extracellular multiunit recording in rats, which offers relatively rapid access to neural activity in a large number of cells. Two cell types were identified, which(More)
OBJECTIVES Aim of the study was to describe the sleep of patients with sleep disorders by means of the spectral frequency index (SFx) in comparison to healthy subjects. METHODS Polysomnographic data of two consecutive nights recorded in healthy subjects (n = 18), patients with insomnia (n = 19), snoring (n = 29) and obstructive sleep apnoea (n = 28) were(More)
In a double-blind placebo-controlled psychopharmacological study 263 patients with cognitive impairment were screened and 137 of them were selected (following defined inclusion and exclusion criteria) to participate in a clinical trial (for results of treatment phase see part II, in preparation). The pretreatment state was evaluated twice using(More)
The aim of this investigation was to objectify the pharmacodynamic effects of different dosages of a commercially available plant extract mixture of valerian and hops by means of the quantitative topographical EEG (qEEG) in healthy young adults in comparison to placebo. Two different dosages were applied in two single-blind, cross-over designed observation(More)
A new system for complete automated sleep analysis has been developed (Somnoscript2000). Eighteen healthy young volunteers (ages 21-28 years, 9 females and 9 males) underwent a complete polysomnographic (PSG) registration. EEG from 17 electrode positions was recorded simultaneously with the polygraphic parameters (CATEEM(R)). The characterization of the(More)