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- Ashley Harris Beecham, Nikolaos A. Patsopoulos, +190 authors Jacob L. McCauley
- Nature Genetics
- 2013
Using the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple sclerosis and 24,091 healthy controls for 161,311 autosomal variants and identified 135 potentially associated… (More)
- Alastair Wilkins, Henry H Majed, Robert Layfield, Alastair D Compston, Siddharthan Chandran
- The Journal of neuroscience : the official…
- 2003
Interactions of CNS cells lead to the establishment of complex neural systems. Specifically, oligodendrocytes form myelin sheaths around axons that enable rapid electrical conduction of impulses.… (More)
- Joanne L Jones, Jane Marian Anderson, +10 authors Alasdair John Coles
- Brain : a journal of neurology
- 2010
Treatment of early relapsing-remitting multiple sclerosis with the lymphocyte-depleting humanized monoclonal antibody alemtuzumab (Campath [registered trade mark]) significantly reduced the risk of… (More)
Neurons and glia interact in the development of mammalian central nervous systems and in the maintenance of stable myelinated axons. Recent evidence suggests a role for oligodendrocytes in providing… (More)
- Kevin C Kemp, Kelly M Hares, Elizabeth A Mallam, Kate J Heesom, Neil J. Scolding, Alastair Wilkins
- Journal of neurochemistry
- 2010
It has been postulated that bone marrow-derived mesenchymal stem cells (MSCs) might be effective treatments for neurodegenerative disorders either by replacement of lost cells by differentiation into… (More)
- Kevin C Kemp, Elizabeth J Gray, Elizabeth A Mallam, Neil J. Scolding, Alastair Wilkins
- Stem Cell Reviews and Reports
- 2010
Increasing evidence suggests that bone marrow derived-mesenchymal stem cells (MSCs) have neuroprotective properties and a major mechanism of action is through their capacity to secrete a diverse… (More)
- Kevin C Kemp, Amelia J Cook, Juliana Redondo, K. M. Kurian, Neil J. Scolding, Alastair Wilkins
- Acta neuropathologica communications
- 2016
Purkinje cell pathology is a common finding in a range of inherited and acquired cerebellar disorders, with the degree of Purkinje cell injury dependent on the underlying aetiology. Purkinje cells… (More)
- Alastair Wilkins, Kevin C Kemp, Mark Ginty, Kelly M Hares, Elizabeth A Mallam, Neil J. Scolding
- Stem cell research
- 2009
Bone marrow-derived mesenchymal stem cells (MSCs) are of therapeutic interest in a variety of neurological diseases. In this study, we wished to determine whether human MSCs secrete factors which… (More)
- Jonathan Witherick, Alastair Wilkins, Neil J. Scolding, Kevin C Kemp
- Autoimmune diseases
- 2010
Although significant advances have recently been made in the understanding and treatment of multiple sclerosis, reduction of long-term disability remains a key goal. Evidence suggests that… (More)
- Alastair Wilkins, Neil J. Scolding
- Multiple sclerosis
- 2008
Typically patients with multiple sclerosis (MS) experience acute episodes of neurological dysfunction, which recover followed, at a later stage, by slow and insidious accumulation of disability… (More)